| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Characterization of E-cadherin expression in normal mucosa, dysplasia and adenocarcinoma of gastric cardia and its influence on prognosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-Ling Wang, Xue-Ke Zhao, Fu-You Zhou, Xin Song, Liu-Yu Li, Gai-Rong Huang, Qi-De Bao, Ling-Ling Lei, Hai-Jun Yang, Li Li, Rui-Hua Xu, Ai-Li Li, Xian-Zeng Wang, Wen-Li Han, Jing-Li Ren and Li-Dong Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81872032 |
| National Natural Science Foundation of China |
U1804262 |
| National Key R&D Program of China |
2016YFC0901403 |
|
| Corresponding Author |
Li-Dong Wang, MD, PhD, Professor, State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, No. 40 Daxue Road, Zhengzhou 450052, Henan Province, China. ldwang2007@126.com |
| Key Words |
E-cadherin expression; Immunohistochemistry; Gastric cardia adenocarcinoma; Dysplasia; Clinicopathological feature; Prognosis |
| Core Tip |
In previous reports, there is no consistent conclusion on the association between E-cadherin expression and gastric cardia carcinogenesis and its effect on prognosis with gastric cardia adenocarcinoma (GCA) patients. It was notable that the positive immunostaining rates of E-cadherin decreased significantly from normal mucosa to dysplasia and GCA, as well as higher in early stage than those in advanced stage of GCA. Moreover, we found high expression of E–cadherin represented a better survival, especially for patients with negative lymph node metastasis. In conclusion, E-cadherin may be involved in carcinogenesis and may be a predictor on prognosis for GCA. |
| Publish Date |
2022-01-11 00:11 |
| Citation |
Wang HL, Zhao XK, Zhou FY, Song X, Li LY, Huang GR, Bao QD, Lei LL, Yang HJ, Li L, Xu RH, Li AL, Wang XZ, Han WL, Ren JL, Wang LD. Characterization of E-cadherin expression in normal mucosa, dysplasia and adenocarcinoma of gastric cardia and its influence on prognosis. World J Gastrointest Oncol 2022; 14(1): 265-277 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i1/265.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i1.265 |
