Publication Name	World Journal of Gastroenterology
Manuscript ID	71482
Country	Italy

Received	2021-09-09 10:52
Peer-Review Started	2021-09-09 10:53
To Make the First Decision
Return for Revision	2021-11-21 20:21
Revised	2021-12-05 19:33
Second Decision	2022-03-02 06:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-03-06 22:54
Articles in Press	2022-03-06 22:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-02-27 15:08
Typeset the Manuscript	2022-03-30 07:38
Publish the Manuscript Online	2022-04-06 08:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Osteosarcopenia in autoimmune cholestatic liver diseases: Causes, management, and challenges
Manuscript Source	Invited Manuscript
All Author List	Nicola Pugliese, Ivan Arcari, Alessio Aghemo, Andrea G Lania, Ana Lleo and Gherardo Mazziotti
Funding Agency and Grant Number
Corresponding Author	Ana Lleo, MD, PhD, Professor, Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele 20090, Milan, Italy. ana.lleo@humanitas.it
Key Words	Cholestatic liver diseases; Primary biliary cholangitis; Primary sclerosing cholangitis; Osteoporosis; Sarcopenia
Core Tip	Cholestatic liver diseases (CLD) in adults are characterized by an immune pathogenesis. Osteoporosis is the most common bone disease in CLD, resulting in frequent fractures and leading to significant morbidity. Sarcopenia is emerging as a frequent complication with a significant prognostic impact and severe implications on the quality of life of patients. The lack of useful preventive measures and efficacious treatment strategies remains one of the largest challenges in the management of patients with CLD.
Publish Date	2022-04-06 08:50
Citation	Pugliese N, Arcari I, Aghemo A, Lania AG, Lleo A, Mazziotti G. Osteosarcopenia in autoimmune cholestatic liver diseases: Causes, management, and challenges. World J Gastroenterol 2022; 28(14): 1430-1443
URL	https://www.wjgnet.com/1007-9327/full/v28/i14/1430.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i14.1430

Full Article (PDF)	WJG-28-1430.pdf
Full Article (Word)	WJG-28-1430.docx
Manuscript File	71482_Auto_Edited-JRF-Wang TQ.docx
Answering Reviewers	71482-Answering reviewers.pdf
Audio Core Tip	71482-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	71482-Conflict-of-interest statement.pdf
Copyright License Agreement	71482-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	71482-Language certificate.pdf
Peer-review Report	71482-Peer-review(s).pdf
Scientific Misconduct Check	71482-Bing-Fan JR-2.png
Scientific Editor Work List	71482-Scientific editor work list.pdf