| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer’s disease mouse model
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying Xiong, Yu-Ting Ruan, Jing Zhao, Yu-Wen Yang, Li-Ping Chen, Ying-Ren Mai, Qun Yu, Zhi-Yu Cao, Fei-Fei Liu, Wang Liao and Jun Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81870836 |
| Natural Science Foundation of Guangdong Province, China |
2020A1515010210 |
| Science and Technology Program of Guangzhou, China |
202007030010 |
| Guangdong Basic and Applied Basic Research Foundation, China |
2020A1515110317 |
| Guangdong Basic and Applied Basic Research Foundation |
2021A1515010705 |
|
| Corresponding Author |
Jun Liu, MD, Professor, Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 Yanjiang West Road, Guangzhou 510120, Guangdong Province, China. liujun6@mail.sysu.edu.cn |
| Key Words |
Alzheimer’s disease; Magnesium; Neuroprotective effect; Oxidative stress; Hippocampal; Neuronal apoptosis |
| Core Tip |
The dysfunction of oxidative stress is considered to stimulate the production of reactive oxygen species and induce hippocampal neuron damage which are the significant hallmarks of neurodegenerative diseases such as Alzheimer’s disease. Recent studies have explored the in vitro anti-malondialdehyde effect of magnesium. However, the potential neuroprotective effect of Magnesium-L-threonate (MgT) against oxidative stress remains to be explored. Our study demonstrated that MgT exhibited neuroprotective effects on suppressing oxidative stress and hippocampal neuronal apoptosis in vitro and in vivo, suggesting the promising therapeutic potential of MgT in oxidative stress-associated neurodegenerative disorders. |
| Publish Date |
2022-03-18 12:26 |
| Citation |
Xiong Y, Ruan YT, Zhao J, Yang YW, Chen LP, Mai YR, Yu Q, Cao ZY, Liu FF, Liao W, Liu J. Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer’s disease mouse model. World J Psychiatr 2022; 12(3): 410-424 |
| URL |
https://www.wjgnet.com/2220-3206/full/v12/i3/410.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v12.i3.410 |
