| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
Microbiologic risk factors of recurrent choledocholithiasis post-endoscopic sphincterotomy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying Li, Jia-Chuan Wu, Zhi-Xin Huang, Yan-Yan Shang, Biao Liang, Jian-Hui Chen, Rui Pang, Xin-Qiang Xie, Ju-Mei Zhang, Yu Ding, Liang Xue, Mou-Tong Chen, Juan Wang, Wen-Hui Tan and Qing-Ping Wu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangdong Provincial Key Laboratory |
2020B121201009 |
| the Science Foundation of Guangdong Second Provincial General Hospital |
YQ2019-014 |
| GDAS’ Project of Science and Technology Development |
2020GDASYL-20200301002 |
|
| Corresponding Author |
Qing-Ping Wu, PhD, Academic Fellow, Chairman, Professor, Senior Researcher, Senior Scientist, Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, No.66 Yard 100 Xieliezhong Rd, Guangzhou 510070, Guangdong, China. wuqp203@163.com |
| Key Words |
Choledocholithiasis; Biliary tract; Microbiome; Endoscopic sphincterotomy; Recurrence; Lactobacillus |
| Core Tip |
Treatment of choledocholithiasis by endoscopic sphincterotomy (EST) has become widespread, but recurrence post-EST is relatively common. In this study, we analyzed the bile microbiome of patients with recurrent choledocholithiasis. Increase in Fusobacterium and Neisseria, and the absence of Lactobacillus in bile were the key microbiologic features of recurrent choledocholithiasis. Bile microbiome imbalance might cause poor metabolism of carbohydrates and amino acids and increased glycan biosynthesis in the biliary tract, leading to disease recurrence. The microbiological features in bile could be an effective predictor for choledocholithiasis recurrence post-EST. The findings of our study will help develop new prevention strategies for post-surgery recurrence of choledocholithiasis. |
| Publish Date |
2022-03-25 07:42 |
| Citation |
Li Y, Tan WH, Wu JC, Huang ZX, Shang YY, Liang B, Chen JH, Pang R, Xie XQ, Zhang JM, Ding Y, Xue L, Chen MT, Wang J, Wu QP. Microbiologic Risk Factors of Recurrent Choledocholithiasis Post-Endoscopic Sphincterotomy. World J Gastroenterol 2022; 28(12): 1257-1271 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i12/1257.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i12.1257 |
