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8/12/2022 11:50:09 AM | Browse: 480 | Download: 1833
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Received |
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2021-10-18 07:13 |
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Peer-Review Started |
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2021-10-18 07:15 |
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First Decision by Editorial Office Director |
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2021-12-27 07:06 |
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Return for Revision |
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2021-12-27 07:06 |
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Revised |
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2022-01-26 00:11 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-06-22 09:16 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-06-26 23:58 |
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Articles in Press |
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2022-06-26 23:58 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-08-07 14:14 |
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Publish the Manuscript Online |
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2022-08-12 11:48 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Clopidogrel delays and can reverse diabetic nephropathy pathogenesis in type 2 diabetic db/db mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Qin Li, Nian Liu, Zong-Yu Zheng, Hao-Lin Teng and Jin Pei |
| Funding Agency and Grant Number |
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| Corresponding Author |
Jin Pei, PhD, Professor, Department of Biopharmacy, Jilin University School of Pharmaceutical Sciences, No. 1163, Xinmin street, Changchun 130021, Jilin Province, China. peijin@jlu.edu.cn |
| Key Words |
Diabetes; Clopidogrel; Inflammation; Fibronectin; Diabetic nephropathy |
| Core Tip |
Diabetic nephropathy is the most common microvascular inflammatory disease among the diabetic complications. Previous studies have shown that clopidogrel administration is an effective means of suppressing inflammation in diseases such as acute myocardial infarction, diabetes, and acute ischemic cerebral infarction. In this study, we aimed to determine whether treatment with clopidogrel has a preventive or therapeutic effect in the kidneys of obese, type 2 diabetic db/db mice. In this experiment, we demonstrated that clopidogrel significantly reduced renal collagen deposition and fibrosis and prevented renal dysfunction in db/db mice, most likely through inhibition of renal macrophage infiltration and the associated inflammation. |
| Publish Date |
2022-08-12 11:48 |
| Citation |
Li HQ, Liu N, Zheng ZY, Teng HL, Pei J. Clopidogrel delays and can reverse diabetic nephropathy pathogenesis in type 2 diabetic db/db mice. World J Diabetes 2022; 13(8): 600-612
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| URL |
https://www.wjgnet.com/1948-9358/full/v13/i8/600.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v13.i8.600 |
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