Publication Name	World Journal of Gastroenterology
Manuscript ID	72437
Country	Italy

Received	2021-10-15 18:25
Peer-Review Started	2021-10-15 18:27
First Decision by Editorial Office Director	2021-12-12 06:37
Return for Revision	2021-12-12 06:37
Revised	2021-12-24 16:33
Publication Fee Transferred
Second Decision by Editor	2022-02-17 05:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-02-20 12:37
Articles in Press	2022-02-20 12:37
Edit the Manuscript by Language Editor	2022-02-08 01:44
Typeset the Manuscript	2022-03-08 21:49
Publish the Manuscript Online	2022-03-17 03:25

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Rectal neuroendocrine tumors: Current advances in management, treatment, and surveillance
Manuscript Source	Invited Manuscript
All Author List	Camilla Gallo, Roberta Elisa Rossi, Federica Cavalcoli, Federico Barbaro, Ivo Boškoski, Pietro Invernizzi and Sara Massironi
Funding Agency and Grant Number
Corresponding Author	Sara Massironi, MD, PhD, Doctor, Doctor, Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, European Reference Network on Hepatological Diseases, San Gerardo Hospital, Via Pergolesi, 33, Monza 20900, Italy. s.massironi@asst-monza.it
Key Words	Rectal neuroendocrine tumors; Endoscopy; Endoscopic submucosal dissection; Resectable advanced disease; Systemic therapy
Core Tip	Rectal neuroendocrine neoplasms (r-NENs) represent 1%-2% of all rectal tumors, but an increasing incidence rate has been recently reported. Up to 90% of r-NENs are < 10 mm in size, confined to the submucosa, and well-differentiated, so that the endoscopic resection represents their gold-standard therapy. Advanced metastatic NENs are usually poorly differentiated G3 carcinomas treated with chemotherapy, except for rare G1-G2 neoplasms, which can be targeted with less aggressive systemic options. Locally advanced r-NENs invading submucosal layers, with a ≥ 10 mm diameter, but still without distant metastases, represent the real therapeutic challenge among rectal tumors.
Publish Date	2022-03-17 03:25
Citation	Gallo C, Rossi RE, Cavalcoli F, Barbaro F, Boškoski I, Invernizzi P, Massironi S. Rectal neuroendocrine tumors: Current advances in management, treatment, and surveillance. World J Gastroenterol 2022; 28(11): 1123-1138
URL	https://www.wjgnet.com/1007-9327/full/v28/i11/1123.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i11.1123

Full Article (PDF)	WJG-28-1123.pdf
Full Article (Word)	WJG-28-1123.docx
Manuscript File	72437_Auto_Edited-YJM_WangTQ.docx
Answering Reviewers	72437-Answering reviewers.pdf
Audio Core Tip	72437-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	72437-Conflict-of-interest statement.pdf
Copyright License Agreement	72437-Copyright license agreement.pdf
Peer-review Report	72437-Peer-review(s).pdf
Scientific Editor Work List	72437-Scientific editor work list.pdf
CrossCheck Report	72437-CrossCheck report.pdf