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5/26/2022 10:17:24 AM | Browse: 229 | Download: 616
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Received |
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2021-10-26 11:54 |
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Peer-Review Started |
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2021-10-26 11:56 |
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To Make the First Decision |
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Return for Revision |
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2021-12-04 21:40 |
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Revised |
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2022-01-03 11:50 |
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Second Decision |
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2022-04-21 02:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-04-25 22:10 |
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Articles in Press |
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2022-04-25 22:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-04-19 01:21 |
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Typeset the Manuscript |
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2022-04-26 02:59 |
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Publish the Manuscript Online |
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2022-05-26 09:29 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Basic Study |
| Article Title |
Human amniotic fluid stem cell therapy can help regain bladder function in type 2 diabetic rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ching-Chung Liang, Steven W Shaw, Yung-Hsin Huang and Tsong-Hai Lee |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Linkou Chang Gung Memorial Hospital grants |
CMRPG3J0951, CMRPG3H1041-2 |
| Ministry of Science and Technology Taiwan grants |
MOST 107-2314-B-182A-101, MOST 109-2314-B-182A-084 |
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| Corresponding Author |
Tsong-Hai Lee, PhD, Professor, Stroke Center and Department of Neurology, Linkou Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, No. 5, Fu-Hsing Street, Kweishan, Taoyuan 333, Taiwan. thlee@adm.cgmh.org.tw |
| Key Words |
Amniotic fluid; Bladder dysfunction; Diabetes; Insulin; Stem cells |
| Core Tip |
Diabetic patients with bladder dysfunction are often resistant to currently available therapies. Stem cells demonstrate the efficacy in preclinical studies of diabetic bladder dysfunction. Human amniotic fluid stem cells (hAFSCs) can be obtained from amniotic fluid, and phenotypically and genetically stable, indicating that hAFSCs can be used as a novel source of cell therapy. Here, we demonstrated that, although it is insulin but not hAFSCs therapy that can help recover the bladder dysfunction caused by diabetes mellitus (DM), both insulin and hAFSCs treatment can help to regain bladder function to near the levels of control. Our study highlights the potential of hAFSCs for cell replacement and regeneration therapy for DM. |
| Publish Date |
2022-05-26 09:29 |
| Citation |
Liang CC, Shaw SW, Huang YH, Lee TH. Human amniotic fluid stem cell therapy can help regain bladder function in type 2 diabetic rats. World J Stem Cells 2022; 14(5): 330-346 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i5/330.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i5.330 |
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