Publication Name	World Journal of Gastroenterology
Manuscript ID	72747
Country	China

Received	2021-10-27 11:20
Peer-Review Started	2021-10-27 11:23
To Make the First Decision
Return for Revision	2021-12-27 01:39
Revised	2021-12-31 05:40
Second Decision	2022-04-15 02:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-04-15 20:19
Articles in Press	2022-04-15 20:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-05-19 01:41
Publish the Manuscript Online	2022-05-27 11:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Minireviews
Article Title	Advances in medical treatment for pancreatic neuroendocrine neoplasms
Manuscript Source	Invited Manuscript
All Author List	Yuan-Liang Li, Zi-Xuan Cheng, Fu-Huan Yu, Chao Tian and Huang-Ying Tan
Funding Agency and Grant Number	Funding Agency Grant Number National Key R&D Program of China 2019YFB1309704
Corresponding Author	Huang-Ying Tan, MD, PhD, Professor, Department of Integrative Oncology, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Street, Chaoyang District, Beijing 100029, China. tanhuangying@263.net
Key Words	Pancreatic neuroendocrine neoplasms; Advanced neuroendocrine tumors; Medical treatment; Peptide receptor radionuclide therapy; Advances
Core Tip	Pancreatic neuroendocrine neoplasms (PanNENs) are rare neoplasms with strong heterogeneity. The systemic treatment options of advanced PanNENs vary due to the different differentiations, grades and stages and include somatostatin analogs, molecularly targeted agents, cytotoxic chemotherapeutic agents, immune checkpoint inhibitors, and peptide receptor radionuclide therapy. Despite the multiple systemic therapeutic options for PanNENs, problems such as drug resistance, adverse side effects and limited scope of application still exist. Thus, we review the clinical development of medical treatment options, focusing on ongoing clinical studies and the development of novel targeted drugs, to provide a reference for clinicians and researchers.
Publish Date	2022-05-27 11:37
Citation	Li YL, Cheng ZX, Yu FH, Tian C, Tan HY. Advances in medical treatment for pancreatic neuroendocrine neoplasms. World J Gastroenterol 2022; 28(20): 2163-2175
URL	https://www.wjgnet.com/1007-9327/full/v28/i20/2163.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i20.2163

Full Article (PDF)	WJG-28-2163.pdf
Full Article (Word)	WJG-28-2163.docx
Manuscript File	72747_Auto_Edited_LM.docx
Answering Reviewers	72747-Answering reviewers.pdf
Audio Core Tip	72747-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	72747-Conflict-of-interest statement.pdf
Copyright License Agreement	72747-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	72747-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	72747-Language certificate.pdf
Supplementary Material	72747-Supplementary material.pdf
Peer-review Report	72747-Peer-review(s).pdf
Scientific Editor Work List	72747-Scientific editor work list.pdf