BPG is committed to discovery and dissemination of knowledge
Featured Articles
2/22/2022 9:44:39 AM | Browse: 427 | Download: 1892
 |
Received |
|
2021-11-20 19:35 |
|
Peer-Review Started |
|
2021-11-20 19:37 |
|
First Decision by Editorial Office Director |
|
2021-12-26 19:56 |
|
Return for Revision |
|
2021-12-28 19:46 |
|
Revised |
|
2022-01-08 01:36 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2022-02-14 05:28 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2022-02-16 07:17 |
|
Articles in Press |
|
2022-02-16 07:17 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2022-02-17 07:03 |
|
Publish the Manuscript Online |
|
2022-02-22 09:25 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
β-arrestin-2 predicts the clinical response to β-blockers in cirrhotic portal hypertension patients: A prospective study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Sameh A Lashen, Mohammed M Shamseya, Marwa A Madkour, Radwa M Abdel Salam and Sanaa S Mostafa |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Sameh A Lashen, MD, PhD, Associate Professor, Internal Medicine (Hepatology and Gastroenterology division), Faculty of Medicine, Alexandria University, Champollion Street, El-Khartoum Square, Azarita Medical Campus, Alexandria 21521, Egypt. sameh.lashen@alexmed.edu.eg |
| Key Words |
β-arrestin-2; Portal hypertension; Variceal bleeding; Nonselective beta-blockers; Portal congestion index; Variceal ligation |
| Core Tip |
Gastric antral β-Arrestin-2 (β-Arr-2) expression correlates to portal hypertension in terms of esophageal varices and portal gastropathy. A stronger β-Arr-2 expression is associated with a sustained clinical response to nonselective β-blockers (NSBB) with a longer variceal bleeding-free interval. Patients who experienced variceal bleeding while on NSBB had lower baseline serum and tissue expression of β-Arr-2. In patients with responded to NSBB, the expression of β-Arr-2 was reduced after long-term treatment. The serum level of β-Arr-2 correlates to its antral expression and showed high sensitivity and specificity for defining the subgroup of patients who will respond to NSBB. |
| Publish Date |
2022-02-22 09:25 |
| Citation |
Lashen SA, Shamseya MM, Madkour MA, Abdel Salam RM, Mostafa SS. β-arrestin-2 predicts the clinical response to β-blockers in cirrhotic portal hypertension patients: A prospective study. World J Hepatol 2022; 14(2): 429-441
|
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i2/429.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i2.429 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
