Publication Name	World Journal of Gastroenterology
Manuscript ID	73525
Country	United Kingdom

Received	2021-11-23 22:26
Peer-Review Started	2021-11-23 22:28
To Make the First Decision
Return for Revision	2022-01-08 18:46
Revised	2022-01-17 03:04
Second Decision	2022-02-24 06:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-02-27 23:16
Articles in Press	2022-02-27 23:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-03-23 11:33
Publish the Manuscript Online	2022-03-30 15:20

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Basic Study
Article Title	c-MET immunohistochemical expression in sporadic and inflammatory bowel disease associated lesions
Manuscript Source	Unsolicited Manuscript
All Author List	Grant Halliday, Ross J Porter, Catherine J Black, Mark J Arends and Shahida Din
Funding Agency and Grant Number
Corresponding Author	Shahida Din, BSc, FRCP, MBChB, PhD, Consultant Physician-Scientist, Edinburgh Inflammatory Bowel Disease Unit, Western General Hospital, NHS Lothian, Anne Feguson Building , Edinburgh EH4 2XU, United Kingdom. sdin@exseed.ed.ac.uk
Key Words	Inflammatory bowel diseases; Colorectal cancer; Surveillance; Detection; c-MET; Immunohistochemistry
Core Tip	During colonoscopy, an intravenous fluorescent anti-c-MET probe may improve endoscopic detection of dysplasia and cancer. However, c-MET expression in inflammatory bowel disease (IBD) lesions is poorly defined, limiting translational studies. We demonstrate that stronger immunohistochemical c-MET expression is associated with dysplasia and cancer in both sporadic and IBD-associated lesions. Therefore, c-MET expression could be exploited clinically to enhance endoscopic detection of pre-malignant lesions and cancer, particularly in IBD where post-colonoscopy colorectal cancer rates are unacceptably high.
Publish Date	2022-03-30 15:20
Citation	Halliday G, Porter RJ, Black CJ, Arends MJ, Din S. c-MET immunohistochemical expression in sporadic and inflammatory bowel disease associated lesions. World J Gastroenterol 2022; 28(13): 1338-1346
URL	https://www.wjgnet.com/1007-9327/full/v28/i13/1338.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i13.1338

Full Article (PDF)	WJG-28-1338.pdf
Full Article (Word)	WJG-28-1338.docx
The ARRIVE Guidelines	73525-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	73525_Auto_Edited.docx
Answering Reviewers	73525-Answering reviewers.pdf
Audio Core Tip	73525-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	73525-Conflict-of-interest statement.pdf
Copyright License Agreement	73525-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	73525-Institutional review board statement.pdf
Supplementary Material	73525-Supplementary material.pdf
Peer-review Report	73525-Peer-review(s).pdf
Scientific Editor Work List	73525-Scientific editor work list.pdf