Publication Name	World Journal of Gastroenterology
Manuscript ID	7353
Country

Received	2013-11-15 14:13
Peer-Review Started	2013-11-16 13:05
To Make the First Decision	2013-12-16 17:17
Return for Revision	2013-12-17 12:30
Revised	2013-12-31 00:00
Second Decision	2014-07-25 08:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-25 09:28
Articles in Press	2014-07-25 10:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-02 14:52
Publish the Manuscript Online	2014-09-19 19:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Hepatitis C-associated liver carcinogenesis: Role of PML nuclear bodies
Manuscript Source
All Author List	Kerstin Herzer, Guido Gerken and Thomas G Hofmann
Funding Agency and Grant Number
Corresponding Author	Kerstin Herzer, MD, Department for Gastroenterology and Hepatology, University Hospital Essen, Hufeland str. 55, 45122 Essen, Germany. kerstin.herzer@uk-essen.de
Key Words	Hepatitis C virus; Promyelocytic leukemia; Nuclear bodies; Hepatocellular carcinoma; Apoptosis
Core Tip	Escape from immune response and non-responsiveness to interferon-therapy are frequently observed in hepatitis C virus (HCV) infection. HCV infection leads to severe liver disease like cirrhosis and hepatocellular carcinoma and is the major cause for hepatocellular carcinoma and liver transplantation in the western world. Interestingly, HCV interferes with tumor suppressor promyelocytic leukemia (PML) function in apoptosis. PML localises to multi-protein complexes termed nuclear bodies (NBs). The number and the size of PML NBs are increased upon interferon-treatment and PML NBs represent preferential targets in viral infection. Accordingly, PML plays an important role in the antiviral action of interferons.
Publish Date	2014-09-19 19:25
Citation	Herzer K, Gerken G, Hofmann TG. Hepatitis C-associated liver carcinogenesis: Role of PML nuclear bodies. World J Gastroenterol 2014; 20(35): 12367-12371
URL	http://www.wjgnet.com/1007-9327/full/v20/i35/12367.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i35.12367

Full Article (PDF)	WJG-20-12367.pdf
Full Article (Word)	WJG-20-12367.doc
Manuscript File	7353-Review.doc
Answering Reviewers	7353-Answering reviewers.pdf
Copyright License Agreement	7353-Copyright assignment.pdf
Peer-review Report	7353-Peer reviews.pdf
Scientific Misconduct Check	7353-CrossCheck.jpg
Scientific Editor Work List	7353-Scientific editor work list.pdf