BPG is committed to discovery and dissemination of knowledge
Featured Articles
6/24/2022 1:16:16 PM | Browse: 235 | Download: 443
 |
Received |
|
2021-12-04 08:38 |
|
Peer-Review Started |
|
2021-12-04 08:40 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2022-01-08 18:05 |
|
Revised |
|
2022-01-14 04:00 |
|
Second Decision |
|
2022-05-10 02:52 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Company Editor-in-Chief |
|
2022-05-14 07:43 |
|
Articles in Press |
|
2022-05-14 07:43 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2022-06-14 08:34 |
|
Publish the Manuscript Online |
|
2022-06-24 13:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Novel multiplex stool-based assay for the detection of early-stage colon cancer in a Chinese population
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Hong Jiang, Si-Wei Xing, Xuan Tang, Ying Chen, Kang Lin, Lu-Wei He, Mou-Bin Lin and Er-Jiang Tang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Pujiang Program |
21PJD066 |
| Shanghai Municipal Commission of Health and Family Planning |
ZK2019A19 |
| Shanghai Municipal Science and Technology Commission |
19411971500 |
| Shanghai Yangpu District Science and Technology Commission |
YPM202101 |
|
| Corresponding Author |
Er-Jiang Tang, MSc, Statistician, Center for Clinical Research and Translational Medicine, Yangpu Hospital, Tongji University, No. 450 Tengyue Road, Shanghai 200090, China. tangerjiang1988051@163.com |
| Key Words |
Colon cancer; Early screening; Stool biomarker; DNA methylation; Fecal immunochemical test |
| Core Tip |
Stool DNA (sDNA) methylation analysis has a promising application in the early diagnosis of colorectal cancer. However, reliable biomarkers for detecting early-stage colon cancer (ECC) are lacking. In this study, by targeted bisulfite sequencing, we identified a novel multiplex stool-based assay combining three sDNA methylation biomarkers and fecal immunochemical test. Further validation in larger samples by pyrosequencing showed that it enabled the diagnosis of ECC with high sensitivity and specificity throughout the colon. To our knowledge, this is the first study to focus on ECC screening in China. |
| Publish Date |
2022-06-24 13:12 |
| Citation |
Jiang HH, Xing SW, Tang X, Chen Y, Lin K, He LW, Lin MB, Tang EJ. Novel multiplex stool-based assay for the detection of early-stage colon cancer in a Chinese population. World J Gastroenterol 2022; 28(24): 2705-2720 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i24/2705.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i24.2705 |
© 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
