Publication Name	World Journal of Clinical Cases
Manuscript ID	74099
Country	China

Received	2021-12-14 03:54
Peer-Review Started	2021-12-14 03:54
To Make the First Decision
Return for Revision	2022-05-30 00:43
Revised	2022-06-01 08:37
Second Decision	2022-07-14 03:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-07-17 23:15
Articles in Press	2022-07-17 23:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-28 05:49
Publish the Manuscript Online	2022-08-16 01:35

ISSN	2307-8960 (online)
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Category	Genetics & Heredity
Manuscript Type	Case Report
Article Title	Discrepancy between non-invasive prenatal testing result and fetal karyotype caused by rare confined placental mosaicism: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Zhen Li and Guang-Rui Lai
Funding Agency and Grant Number	Funding Agency Grant Number 345 Talent Project of Shengjing Hospital M0298
Corresponding Author	Guang-Rui Lai, MD, PhD, Assistant Professor, Department of Clinical Genetics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. laiguangrui@126.com
Key Words	Non-invasive prenatal testing; Confined placental mosaicism; Copy-number variation sequencing; Karyotype analysis; Case report
Core Tip	We identified that the patient had a rare confined placental mosaicism consisting of 47,XY,+21; 47,XXY; and 46,XY, which caused a discrepancy between non-invasive prenatal testing (NIPT) and fetal karyotype. Although NIPT has high sensitivity and specificity, false negatives and false positives are still possible. It is important to remember that NIPT is just a screening test, and any positive results need to be confirmed with invasive testing. Patients with negative NIPT results still require follow-up ultrasound examination.
Publish Date	2022-08-16 01:35
Citation	Li Z, Lai GR. Discrepancy between non-invasive prenatal testing result and fetal karyotype caused by rare confined placental mosaicism: A case report. World J Clin Cases 2022; 10(24): 8641-8647
URL	https://www.wjgnet.com/2307-8960/full/v10/i24/8641.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i24.8641

Full Article (PDF)	WJCC-10-8641.pdf
Full Article (Word)	WJCC-10-8641.docx
Manuscript File	74099_Auto_Edited-LS.docx
Answering Reviewers	74099-Answering reviewers.pdf
Audio Core Tip	74099-Audio core tip.mp3
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Non-Native Speakers of English Editing Certificate	74099-Language certificate.pdf
Peer-review Report	74099-Peer-review(s).pdf
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Scientific Editor Work List	74099-Scientific editor work list.pdf
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