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7/13/2022 1:34:43 AM | Browse: 194 | Download: 495
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Received |
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2022-01-11 01:48 |
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Peer-Review Started |
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2022-01-11 01:50 |
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2022-03-13 17:09 |
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Revised |
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2022-03-18 03:42 |
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Second Decision |
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2022-05-23 03:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-05-28 07:05 |
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Articles in Press |
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2022-05-28 07:05 |
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Edit the Manuscript by Language Editor |
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2022-05-18 03:43 |
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Typeset the Manuscript |
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2022-07-02 07:34 |
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Publish the Manuscript Online |
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2022-07-13 01:27 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Increased 5-hydroxymethylcytosine is a favorable prognostic factor of Helicobacter pylori-negative gastric cancer patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying-Li Fu, Yan-Hua Wu, Dong-Hui Cao, Zhi-Fang Jia, Ao Shen, Jing Jiang and Xue-Yuan Cao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81874279 |
| Scientific and Technological Development Program of Jilin Province |
20190201093JC |
| Scientific and Technological Development Program of Jilin Province |
20200201326JC |
| Jilin Province Department of Finance |
JLSWSRCZX2020-010 |
| Youth Development Fund from First Hospital of Jilin University |
JDYY11202021 |
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| Corresponding Author |
Xue-Yuan Cao, Doctor, PhD, Professor, Research Scientist, Department of Gastric and Colorectal Surgery, The First Hospital of Jilin University, Xinmin Sreet, Changchun 130000, Jilin Province, China. jd3d2ub@jlu.edu.cn |
| Key Words |
5-hydroxymethylation; 5-hydroxymethylcytosine; Helicobacter pylori; Gastric cancer; Prognosis |
| Core Tip |
Helicobacter pylori (H. pylori) was identified as a class I carcinogen and leads to aberrant DNA methylation/hydroxymethylation. 5-hydroxymethylcytosine plays complex roles in the gene regulation of tumorigenesis and is considered an activating epigenetic mark of hydroxymethylation. We conducted a retrospective cohort study to estimate the predictive value of 5-hydroxymethylcytosine levels in the progression and prognosis of gastric cancer patients with different H. pylori infection statuses. The results indicated that increasing 5-hydroxymethylcytosine is a favorable prognostic factor in gastric cancer patients who were not infected with H. pylori, but no associations were observed in H. pylori-positive gastric cancer patients. |
| Publish Date |
2022-07-13 01:27 |
| Citation |
Fu YL, Wu YH, Cao DH, Jia ZF, Shen A, Jiang J, Cao XY. Increased 5-hydroxymethylcytosine is a favorable prognostic factor of Helicobacter pylori-negative gastric cancer patients. World J Gastrointest Oncol 2022; 14(7): 1295-1306 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i7/1295.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i7.1295 |
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