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9/9/2022 1:12:42 PM | Browse: 35 | Download: 36
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 74903
Country/Territory Italy
Received
2022-03-18 22:41
Peer-Review Started
2022-03-18 22:43
To Make the First Decision
Return for Revision
2022-04-17 03:20
Revised
2022-05-05 21:00
Second Decision
2022-06-29 03:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-07-06 14:47
Articles in Press
2022-07-06 14:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-08-04 17:23
Typeset the Manuscript
2022-08-24 00:28
Publish the Manuscript Online
2022-09-09 12:48
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Immunotherapy for nonalcoholic fatty liver disease-related hepatocellular carcinoma: Lights and shadows
Manuscript Source Invited Manuscript
All Author List Federico Costante, Carlo Airola, Francesco Santopaolo, Antonio Gasbarrini, Maurizio Pompili and Francesca Romana Ponziani
Funding Agency and Grant Number
Corresponding Author Francesca Romana Ponziani, MD, PhD, Additional Professor, Internal Medicine and Gastroenterology-Hepatology Unit, Fondazione Policlinico Univeresitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Roma 00168, Italy. francesca.ponziani@gmail.com
Key Words Hepatocellular carcinoma; Immunotherapy; Liver cancer; Nonalcoholic fatty liver disease; Metabolic dysfunction-associated fatty liver disease; Obesity
Core Tip Complex interactions involving the immune system, angiogenesis and inflammation are associated with the pathogenesis of hepatocellular carcinoma. Recent reviews suggested lower efficacy of immunotherapy in patients with non-viral hepatocellular carcinoma. This calls into question the need to stratify patients to maximize the effectiveness of immunotherapeutic agents. In this study, we provided the latest report on the tumor microenvironment structure and its implications in response to immunotherapy in nonalcoholic fatty liver disease-related hepatocellular carcinoma and also discussed the efficacy of first-line systemic treatment in this patient population.
Publish Date 2022-09-09 12:48
Citation Costante F, Airola C, Santopaolo F, Gasbarrini A, Pompili M, Ponziani FR. Immunotherapy for nonalcoholic fatty liver disease-related hepatocellular carcinoma: Lights and shadows. World J Gastrointest Oncol 2022; 14(9): 1622-1636
URL https://www.wjgnet.com/1948-5204/full/v14/i9/1622.htm
DOI https://dx.doi.org/10.4251/wjgo.v14.i9.1622
Full Article (PDF) WJGO-14-1622.pdf
Full Article (Word) WJGO-14-1622.docx
Manuscript File 74903_Auto_Edited-LM_Kerr C_Clear Copy.docx
Answering Reviewers 74903-Answering reviewers.pdf
Audio Core Tip 74903-Audio core tip.mp4
Conflict-of-Interest Disclosure Form 74903-Conflict-of-interest statement.pdf
Copyright License Agreement 74903-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 74903-Language certificate.pdf
Peer-review Report 74903-Peer-review(s).pdf
Scientific Editor Work List 74903-Scientific editor work list.pdf