Publication Name	World Journal of Gastroenterology
Manuscript ID	7500
Country

Received	2013-11-22 08:17
Peer-Review Started	2013-11-22 21:16
To Make the First Decision	2014-02-14 18:28
Return for Revision	2014-02-18 20:55
Revised	2014-03-19 16:34
Second Decision	2014-05-19 11:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-19 11:15
Articles in Press	2014-05-23 09:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-05 10:33
Publish the Manuscript Online	2014-09-19 19:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Immune reaction and colorectal cancer: Friends or foes?
Manuscript Source
All Author List	Vincenzo Formica, Vittore Cereda, Antonella Nardecchia, Manfredi Tesauro and Mario Roselli
Funding Agency and Grant Number
Corresponding Author	Vincenzo Formica, MD, Medical Oncology Unit, ‘Tor Vergata’ University Hospital, Viale Oxford 81, 00133 Rome, Italy. v.formica1@gmail.com
Key Words	Colitis-associated colorectal cancer; Antitumor immunity; Innate immunity; Adaptive immunity
Core Tip	Immune reactions accompany all stages of colorectal carcinogenesis and cancer progression. Recent evidence has shown that innate immunity pathways play a fundamental role in maintaining colorectal epithelial homeostasis and confer antitumor protection. However an excessive and unresolved innate immune reaction is the base of chronic colitis which is a well-known risk factor for colorectal cancer. Once the tumor has developed a number of immune cells may either favorably take under control its growth (CD45RO+CD8+ T cells) or favor its progression and metastatic spread (T regulatory cells). A fine regulation of all antitumor immune components is therefore necessary to design a proper immune-based therapeutic approach in colorectal cancer care and prevention.
Publish Date	2014-09-19 19:25
Citation	Formica V, Cereda V, Nardecchia A, Tesauro M, Roselli M. Immune reaction and colorectal cancer: Friends or foes? World J Gastroenterol 2014; 20(35): 12407-12419
URL	http://www.wjgnet.com/1007-9327/full/v20/i35/12407.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i35.12407

Full Article (PDF)	WJG-20-12407.pdf
Full Article (Word)	WJG-20-12407.doc
Manuscript File	7500-Review.doc
Answering Reviewers	7500-Answering reviewers.pdf
Copyright License Agreement	7500-Copyright assignment.pdf
Peer-review Report	7500-Peer review.pdf
Scientific Editor Work List	7500-Scientific editor work list.pdf