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9/22/2014 8:45:00 AM | Browse: 593 | Download: 607
Publication Name World Journal of Gastroenterology
Manuscript ID 7500
Country/Territory
Received
2013-11-22 08:17
Peer-Review Started
2013-11-22 21:16
To Make the First Decision
2014-02-14 18:28
Return for Revision
2014-02-18 20:55
Revised
2014-03-19 16:34
Second Decision
2014-05-19 11:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-19 11:15
Articles in Press
2014-05-23 09:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-09-05 10:33
Publish the Manuscript Online
2014-09-19 19:25
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Immune reaction and colorectal cancer: Friends or foes?
Manuscript Source
All Author List Vincenzo Formica, Vittore Cereda, Antonella Nardecchia, Manfredi Tesauro and Mario Roselli
Funding Agency and Grant Number
Corresponding Author Vincenzo Formica, MD, Medical Oncology Unit, ‘Tor Vergata’ University Hospital, Viale Oxford 81, 00133 Rome, Italy. v.formica1@gmail.com
Key Words Colitis-associated colorectal cancer; Antitumor immunity; Innate immunity; Adaptive immunity
Core Tip Immune reactions accompany all stages of colorectal carcinogenesis and cancer progression. Recent evidence has shown that innate immunity pathways play a fundamental role in maintaining colorectal epithelial homeostasis and confer antitumor protection. However an excessive and unresolved innate immune reaction is the base of chronic colitis which is a well-known risk factor for colorectal cancer. Once the tumor has developed a number of immune cells may either favorably take under control its growth (CD45RO+CD8+ T cells) or favor its progression and metastatic spread (T regulatory cells). A fine regulation of all antitumor immune components is therefore necessary to design a proper immune-based therapeutic approach in colorectal cancer care and prevention.
Publish Date 2014-09-19 19:25
Citation Formica V, Cereda V, Nardecchia A, Tesauro M, Roselli M. Immune reaction and colorectal cancer: Friends or foes? World J Gastroenterol 2014; 20(35): 12407-12419
URL http://www.wjgnet.com/1007-9327/full/v20/i35/12407.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i35.12407
Full Article (PDF) WJG-20-12407.pdf
Full Article (Word) WJG-20-12407.doc
Manuscript File 7500-Review.doc
Answering Reviewers 7500-Answering reviewers.pdf
Copyright License Agreement 7500-Copyright assignment.pdf
Peer-review Report 7500-Peer review.pdf
Scientific Editor Work List 7500-Scientific editor work list.pdf