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5/17/2022 1:21:44 PM | Browse: 174 | Download: 289
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Received |
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2022-01-17 14:01 |
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Peer-Review Started |
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2022-01-17 14:02 |
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To Make the First Decision |
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Return for Revision |
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2022-02-07 08:23 |
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Revised |
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2022-02-18 16:55 |
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Second Decision |
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2022-03-30 02:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-04-04 05:57 |
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Articles in Press |
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2022-04-04 05:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-04-18 02:24 |
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Publish the Manuscript Online |
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2022-05-17 12:57 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Minireviews |
| Article Title |
Minireview: Mechanisms of ductular reaction in non-alcoholic steatohepatitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yue Chen, Wen-Kang Gao, Yan-Yun Shu and Jin Ye |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81770582 |
| Graduates’ Innovation Fund, Huazhong University of Science and Technology |
2021yjsCXCY106 |
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| Corresponding Author |
Jin Ye, MD, PhD, Chief Doctor, Professor, Division of Gastroenterology, Union Hospital, Tongji Medical college, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei, China. yejin8688@sina.com |
| Key Words |
Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Ductular reaction; Mechanisms; Signaling pathways |
| Core Tip |
With the increasing prevalence of obesity and hyperlipidemia, Non-alcoholic fatty liver disease (NAFLD) has become the primary cause of chronic liver disease worldwide. Thus, the pathogenesis of non-alcoholic steatohepatitis (NASH) is drawing increasing attention. Ductular reaction (DR) is a reactive bile duct hyperplasia involving hepatocytes, cholangiocytes, and hepatic progenitor cells, that plays an important role in NAFLD pathogenesis and promotes the occurrence and development of NASH and liver fibrosis. This minireview describes the characteristics of DR and summarizes its pivotal mechanisms. A role for DR during NASH is described that supplements current knowledge about the pathogenesis of this disease and informs potential prevention and treatment strategies. |
| Publish Date |
2022-05-17 12:57 |
| Citation |
Chen Y, Gao WK, Shu YY, Ye J. Minireview: Mechanisms of ductular reaction in non-alcoholic steatohepatitis. World J Gastroenterol 2022; 28(19): 28(19): 2088-2099 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i19/2088.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i19.2088 |
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