Publication Name	World Journal of Gastroenterology
Manuscript ID	75195
Country	United States

Received	2022-01-18 02:18
Peer-Review Started	2022-01-18 02:19
To Make the First Decision
Return for Revision	2022-04-11 06:54
Revised	2022-04-24 14:55
Second Decision	2022-07-01 03:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-07-06 03:12
Articles in Press	2022-07-06 03:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-25 02:39
Publish the Manuscript Online	2022-08-03 07:54

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Oncology
Manuscript Type	Review
Article Title	Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Eid Alshammari, Ying-Xue Zhang and Zhe Yang
Funding Agency and Grant Number
Corresponding Author	Zhe Yang, PhD, Associate Professor, Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine , 540 E Canfield St, Detroit, MI 48201, United States. zyang@med.wayne.edu
Key Words	Pancreatic ductal adenocarcinoma; Protein lysine methyltransferase; Histone/non-histone methylation; Oncogenic signaling pathways; Methyltransferase inhibitors
Core Tip	The broad substrate specificity of SET and MYND domain-containing protein 2 (SMYD2) and its involvement in diverse oncogenic signaling pathways in numerous cancers have provided a wealth of information that could be extrapolated to the pancreatic ductal adenocarcinoma (PDAC) research field to expand our understanding of SMYD2 in PDAC development. This review not only discusses the known roles of SMYD2 in PDAC initiation and progression, but also aims to capitalize on a rich body of knowledge with respect to SMYD2’s involvement in various signaling cascades to develop new hypotheses about the mechanisms of driving PDAC tumor growth and metastasis.
Publish Date	2022-08-03 07:54
Citation	Alshammari E, Zhang YX, Yang Z. Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer. World J Gastroenterol 2022; 28(29): 3753-3766
URL	https://www.wjgnet.com/1007-9327/full/v28/i29/3753.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i29.3753

Full Article (PDF)	WJG-28-3753.pdf
Full Article (Word)	WJG-28-3753.docx
Manuscript File	75195_Auto_Edited-LS.docx
Answering Reviewers	75195-Answering reviewers.pdf
Audio Core Tip	75195-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	75195-Conflict-of-interest statement.pdf
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Non-Native Speakers of English Editing Certificate	75195-Language certificate.pdf
Peer-review Report	75195-Peer-review(s).pdf
Scientific Misconduct Check	75195-Bing-Chen YL-2.png
Scientific Editor Work List	75195-Scientific editor work list.pdf