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7/22/2022 10:09:42 AM | Browse: 350 | Download: 1276
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Received |
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2022-02-05 09:06 |
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Peer-Review Started |
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2022-02-05 09:08 |
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First Decision by Editorial Office Director |
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2022-05-12 08:45 |
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Return for Revision |
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2022-05-12 08:45 |
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Revised |
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2022-06-01 11:24 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-06-20 03:04 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-06-27 00:03 |
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Articles in Press |
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2022-06-27 00:03 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-07-01 07:21 |
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Publish the Manuscript Online |
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2022-07-22 09:38 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Retrospective Study |
| Article Title |
Necessity of neutrophil-to-lymphocyte ratio monitoring for hypothyroidism using nivolumab in patients with cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ako Gannichida, Yusuke Nakazawa, Akira Kageyama, Hirofumi Utsumi, Kazuyoshi Kuwano and Takashi Kawakubo |
| Funding Agency and Grant Number |
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| Corresponding Author |
Yusuke Nakazawa, MDS, Assistant Lecturer, Department of Pharmacy, The Jikei University Hospital, 3-19-18 Nishi Shimbashi, Minato-ku, Tokyo 105-8471, Japan, Tokyo 105-8471, Japan. y_nakazawa@jikei.ac.jp |
| Key Words |
Nivolumab; Hypothyroidism; Immune checkpoint inhibitors; Immune-related adverse event; Neutrophil-to-lymphocyte ratio |
| Core Tip |
This study evaluated whether continuous monitoring of neutrophil-to-lymphocyte ratio (NLR) during nivolumab treatment is useful for predicting the incidence and onset period of hypothyroidism. Patients with hypothyroidism had a significantly lower NLR at treatment initiation, and hypothyroidism incidence was higher among those with NLR < 5. Patients with persistently low NLR (<3.5) developed hypothyroidism earlier than those with an NLR of 3.5 to <5 and ≥5. Low NLR at treatment initiation increases the incidence of treatment-induced hypothyroidism. Furthermore, its persistence may be a risk factor for the early onset of hypothyroidism. |
| Publish Date |
2022-07-22 09:38 |
| Citation |
Gannichida A, Nakazawa Y, Kageyama A, Utsumi H, Kuwano K, Kawakubo T. Necessity of neutrophil-to-lymphocyte ratio monitoring for hypothyroidism using nivolumab in patients with cancer. World J Clin Oncol 2022; 13(7): 641-651 |
| URL |
https://www.wjgnet.com/2218-4333/full/v13/i7/641.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v13.i7.641 |
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