Publication Name	World Journal of Stem Cells
Manuscript ID	75421
Country	India

Received	2022-01-28 07:44
Peer-Review Started	2022-01-28 07:46
To Make the First Decision
Return for Revision	2022-03-11 23:43
Revised	2022-03-25 05:32
Second Decision	2022-05-07 07:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-08 07:17
Articles in Press	2022-05-08 07:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-04-28 20:53
Typeset the Manuscript	2022-05-23 07:36
Publish the Manuscript Online	2022-05-26 09:29

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Basic Study
Article Title	Soluble factors secreted by human Wharton’s jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection-a mechanistic study with integrating network biology
Manuscript Source	Invited Manuscript
All Author List	Dharmendra Kumar Maurya, Mayuri Bandekar and Santosh Kumar Sandur
Funding Agency and Grant Number
Corresponding Author	Dharmendra Kumar Maurya, BSc, MSc, PhD, N/A, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, 3-82-S, A-block, Modular Laboratory, Mumbai 400085, Maharashtra, India. dkmaurya@barc.gov.in
Key Words	Radioprotection; Mesenchymal stem cells; Wharton's jelly-derived mesenchymal stromal/stem cells; Cytokines; Granulocyte-colony stimulating factor; Network biology
Core Tip	This study showed the potential role of cytokine granulocyte-colony stimulating factor in therapeutic radioprotection. Transcriptome analysis shows that Wharton's jelly-derived mesenchymal stromal/stem cells (WJ-MSCs) have unique set of genes compared to bone marrow MSCs and embryonic stem cells. WJ-MSCs secrete several cytokines which promote cellular pathways which handle tissue repair and regeneration.
Publish Date	2022-05-26 09:29
Citation	Maurya DK, Bandekar M, Sandur SK. Soluble factors secreted by human Wharton’s jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology. World J Stem Cells 2022; 14(5): 347-361
URL	https://www.wjgnet.com/1948-0210/full/v14/i5/347.htm
DOI	https://dx.doi.org/10.4252/wjsc.v14.i5.347

Full Article (PDF)	WJSC-14-347.pdf
Full Article (Word)	WJSC-14-347.docx
Manuscript File	75421_Auto_Edited-JRF-Filipodia CL.docx
Answering Reviewers	75421-Answering reviewers.pdf
Audio Core Tip	75421-Audio core tip.m4a
Biostatistics Review Certificate	75421-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	75421-Conflict-of-interest statement.pdf
Copyright License Agreement	75421-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	75421-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	75421-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	75421-Language certificate.pdf
Supplementary Material	75421-Supplementary material.pdf
Peer-review Report	75421-Peer-review(s).pdf
Scientific Misconduct Check	75421-Bing-Fan JR-2.png
Scientific Editor Work List	75421-Scientific editor work list.pdf