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7/27/2022 1:20:42 PM | Browse: 24 | Download: 32
Publication Name World Journal of Hepatology
Manuscript ID 75549
Country/Territory Argentina
2022-02-03 19:51
Peer-Review Started
2022-02-03 19:53
To Make the First Decision
Return for Revision
2022-04-08 08:29
2022-04-13 22:45
Second Decision
2022-06-06 03:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-06-17 22:36
Articles in Press
2022-06-17 22:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-07-01 03:59
Publish the Manuscript Online
2022-07-27 13:17
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Editorial
Article Title Checkpoint inhibitor-induced hepatotoxicity: Role of liver biopsy and management approach
Manuscript Source Invited Manuscript
All Author List Fernando Bessone and Einar Stefan Bjornsson
Funding Agency and Grant Number
Corresponding Author Fernando Bessone, MD, Full Professor, Department of Gastroenterology and Hepatology, Facultad de Ciencias Médicas, Hospital Provincial del Centenario, University of Rosario School of Medicine, Urquiza 3101, Rosario 2000, Santa Fe, Argentina. bessonefernando@gmail.com
Key Words Hepatotoxicity; Checkpoint inhibitors; Biologics; hepatitis; Drug-induced liver injury; Liver biopsy
Core Tip Liver injury associated with immunological checkpoint inhibitors (ICIs) has been reported in 3%-8% of patients with grade III-IV hepatitis in retrospective studies. Although there are no distinctive histological features, the finding of granulomas and endothelitis may suggest a specific type of hepatitis induced by ICIs. Recent studies have demonstrated that 33-50% of patients improve spontaneously with discontinuation of ICIs. The high doses of corticosteroids with 1-2 mg/kg/d of methylprednisolone recommended by the oncological societies are controversial. Patients with ICI induced hepatoxicity without jaundice and/or coagulopathy should be monitored.
Publish Date 2022-07-27 13:17
Citation Bessone F, Bjornsson ES. Checkpoint inhibitor-induced hepatotoxicity: Role of liver biopsy and management approach. World J Hepatol 2022; 14(7): 1269-1276
URL https://www.wjgnet.com/1948-5182/full/v14/i7/1269.htm
DOI https://dx.doi.org/10.4254/wjh.v14.i7.1269
Full Article (PDF) WJH-14-1269.pdf
Full Article (Word) WJH-14-1269.docx
Manuscript File 75549_Auto_Edited-LJH-LS.docx
Answering Reviewers 75549-Answering reviewers.pdf
Audio Core Tip 75549-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 75549-Conflict-of-interest statement.pdf
Copyright License Agreement 75549-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 75549-Language certificate.pdf
Peer-review Report 75549-Peer-review(s).pdf
Scientific Misconduct Check 75549-Bing-Liu JH-2.jpg
Scientific Misconduct Check 75549-CrossCheck.jpg
Scientific Editor Work List 75549-Scientific editor work list.pdf