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10/13/2014 12:01:00 PM | Browse: 494 | Download: 787
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2013-11-26 14:08 |
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Peer-Review Started |
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2013-11-26 23:14 |
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2014-02-13 16:15 |
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Return for Revision |
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2014-02-20 20:37 |
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2014-03-10 05:25 |
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Second Decision |
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2014-06-03 16:18 |
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Accepted by Journal Editor-in-Chief |
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2014-06-03 16:32 |
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Articles in Press |
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2014-06-03 16:49 |
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Typeset the Manuscript |
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2014-08-29 15:18 |
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Publish the Manuscript Online |
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2014-09-11 10:03 |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Mnk kinase pathway: Cellular functions and biological outcomes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Keith James Collard |
| Funding Agency and Grant Number |
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| Corresponding Author |
Sonali Joshi, Ph.D., Postdoctoral Fellow, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit Number: 108, Houston, TX 77030, United States. ssjoshi@mdanderson.org Telephone:+ 1-713-794-1233, Fax: +1-713-792-4454
or
Platanias LC, M.D., Ph.D., Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, and Jesse Brown VA Medical Center, Chicago, IL 60611, United States. l-platanias@northwestern.edu Telephone: +1-312-5034267, Fax: +1-312-9081372
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| Key Words |
Mnk kinases; MAPKs; eIF4E; mRNA translation; Cancer |
| Core Tip |
This review focuses on the the pathways regulating the activity of the MAPK interacting protein kinases (Mnk kinases), the effectors of the Mnk kinases and the biological functions of the Mnk kinases. The Mnk pathway is under extensive study due to its regulation of the mRNA cap binding protein eIF4E and its role in mRNA translation in various malignancies. As discussed in the review, development of Mnk inhibitors will have important broad spectrum clinical implications. |
| Publish Date |
2014-09-11 10:03 |
| Citation |
Joshi S, Platanias LC. Mnk kinase pathway: Cellular functions and biological outcomes. World J Biol Chem 2014; 5(3): 321-333 |
| URL |
http://www.wjgnet.com/1949-8454/full/v5/i3/321.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v5.i3.321 |
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