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7/27/2022 1:20:42 PM | Browse: 24 | Download: 25
Publication Name World Journal of Hepatology
Manuscript ID 76109
Country/Territory United States
Received
2022-03-02 00:32
Peer-Review Started
2022-03-02 00:33
To Make the First Decision
Return for Revision
2022-04-13 11:22
Revised
2022-04-29 22:17
Second Decision
2022-06-06 03:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-06-17 22:36
Articles in Press
2022-06-17 22:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-07-14 00:13
Publish the Manuscript Online
2022-07-27 13:17
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Clinical and Translational Research
Article Title Transcriptome changes in stages of non-alcoholic fatty liver disease
Manuscript Source Unsolicited Manuscript
All Author List Jihad Aljabban, Michael Rohr, Saad Syed, Kamal Khorfan, Vincent Borkowski, Hisham Aljabban, Michael Segal, Mohamed Mukhtar, Mohammed Mohammed, Maryam Panahiazar, Dexter Hadley, Ryan Spengler and Erin Spengler
Funding Agency and Grant Number
Corresponding Author Jihad Aljabban, MD, MSc, Academic Research, Doctor, Department of Medicine, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, Madison, WI 53792, United States. jaljabban@uwhealth.org
Key Words Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Bioinformatics; AKT inhibitor; Therapy
Core Tip Our results from the NAFLD analysis reinforce the role of altered metabolism, inflammation, and cell survival in pathogenesis and support recently described contributors to disease activity, such as altered androgen and lncrna activity. The top upstream regulator was found to be SREBF1, a transcription factor involved in lipid homeostasis. Downstream of SREBF1, we observed upregulation in CXCL10, HMGCR, HMGCS1, FABP5, PEG10, and downregulation of SHBG and IGF1. These molecular changes reflect low-grade inflammation secondary to accumulation of fatty acids in the liver. Our results from the NASH analysis emphasized the role of cholesterol in pathogenesis. Top upstream regulators included pro-inflammatory cytokines TNF and IL1B, PDGF BB, and beta-estradiol. Inhibition of beta-estradiol was shown to be related to derangement of several cellular downstream processes including metabolism, extracellular matrix deposition, and tumor suppression. Lastly, we found riciribine (an AKT inhibitor) and ZSTK-474 (a PI3K inhibitor) as potential drugs that targeted the differential gene expression in our dataset.
Publish Date 2022-07-27 13:17
Citation Aljabban J, Rohr M, Syed S, Khorfan K, Borkowski V, Aljabban H, Segal M, Mukhtar M, Mohammed M, Panahiazar M, Hadley D, Spengler R, Spengler E. Transcriptome changes in stages of non-alcoholic fatty liver disease. World J Hepatol 2022; 14(7): 1382-1397
URL https://www.wjgnet.com/1948-5182/full/v14/i7/1382.htm
DOI https://dx.doi.org/10.4254/wjh.v14.i7.1382
Full Article (PDF) WJH-14-1382.pdf
Full Article (Word) WJH-14-1382.docx
Manuscript File 76109_Auto_Edited-LS.docx
Answering Reviewers 76109-Answering reviewers.pdf
Audio Core Tip 76109-Audio core tip.mp3
Biostatistics Review Certificate 76109-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 76109-Conflict-of-interest statement.pdf
Copyright License Agreement 76109-Copyright license agreement.pdf
Peer-review Report 76109-Peer-review(s).pdf
Scientific Misconduct Check 76109-Bing-Wang LL-2.png
Scientific Editor Work List 76109-Scientific editor work list.pdf