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9/7/2022 12:12:15 PM | Browse: 370 | Download: 975
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Received |
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2022-03-14 11:28 |
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Peer-Review Started |
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2022-03-14 11:30 |
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First Decision by Editorial Office Director |
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2022-04-11 21:07 |
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Return for Revision |
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2022-04-11 21:07 |
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Revised |
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2022-05-15 13:14 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-08-18 03:13 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-08-22 17:09 |
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Articles in Press |
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2022-08-22 17:09 |
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Edit the Manuscript by Language Editor |
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2022-08-16 13:18 |
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Typeset the Manuscript |
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2022-09-01 05:55 |
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Publish the Manuscript Online |
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2022-09-07 08:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Oxidized low-density lipoprotein stimulates CD206 positive macrophages upregulating CD44 and CD133 expression in colorectal cancer with high-fat diet
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Min Zheng, Hao Chen, Wei-Hong Sha, Xiao-Fen Chen, Jian-Bin Yin, Xiao-Bo Zhu, Zhong-Wen Zheng and Juan Ma |
| Funding Agency and Grant Number |
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| Corresponding Author |
Juan Ma, PhD, Doctor, Doctor, Department of Gastroenterology and Hepatology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province, China. mjlqh@163.com |
| Key Words |
Oxidized low-density lipoprotein; CD206 positive macrophages; CD44; CD133 |
| Core Tip |
Obesity increases the risk of colorectal cancer (CRC), but the mechanism remains unknown. CD206+ macrophages promote CRC. It has been established that the prevalence of CRC was higher in people consuming a high-fat diet (HFD) and HFD fed mice with up-regulated CD206+ macrophages levels in colorectal tissue. Oxidized low-density lipoprotein (ox-LDL) is a lipid peroxide which has been found to be increased in serum of CRC patients. Importantly, ox-LDL exerts a regulatory effect on macrophages and may regulate CRC through the tumor microenvironment. Our study showed that ox-LDL stimulates CD206+ macrophages to up-regulate CD44 and CD133 expression in HFD associated CRC. |
| Publish Date |
2022-09-07 08:29 |
| Citation |
Zheng SM, Chen H, Sha WH, Chen XF, Yin JB, Zhu XB, Zheng ZW, Ma J. Oxidized low-density lipoprotein stimulates CD206 positive macrophages upregulating CD44 and CD133 expression in colorectal cancer with high-fat diet. World J Gastroenterol 2022; 28(34): 4993-5006 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i34/4993.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i34.4993 |
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