| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
Immunological mechanisms of fecal microbiota transplantation in recurrent Clostridioides difficile infection
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Lucas F Soveral, Gabriela G Korczaguin, Pedro S Schmidt, Isabel S Nunes, Camilo Fernandes and Carlos R Zárate-Bladés |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| “Programa de ciência, tecnologia e inovação aos grupos de pesquisa da Universidade Federal de Santa Catarina”, FAPESC |
2021TR000301 |
| Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina, FAPESC |
3003/2021 |
| Programa Institucional de Iniciação Cientifica e Tecnológica, PIBIC of the Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq |
2021/949248 |
| Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES |
202003075 |
|
| Corresponding Author |
Carlos R Zárate-Bladés, MD, MSc, PhD, Assistant Professor, Laboratory of Immunoregulation, Department of Microbiology, Immunology, and Parasitology, Center for Dysbiosis Control, Federal University of Santa Catarina, CCB Novo, 8o andar, Rua da Prefeitura Universitária, Setor Córrego Grande, Campus UFSC, Florianopolis 88037-000, Brazil. zarate.blades@ufsc.br |
| Key Words |
Fecal microbiota transplantation; Immunity; Mechanism; Dysbiosis; Pseudomembranous colitis; Clostridioides difficile |
| Core Tip |
Fecal microbiota transplantation (FMT) is an excellent treatment option of pseudomembranous colitis due to Clostridiodes difficile infection (CDI) because of its remarkable effectiveness. Moreover, FMT is a promising therapy for several other disorders in which dysbiosis is an important pathological factor. The mechanisms of FMT have begun to be dissected and include the restoration of the commensal microbial community structure and the modulation of several components of the immune system. This minireview focus on the FMT immune-related mechanisms for CDI. |
| Publish Date |
2022-08-31 11:27 |
| Citation |
Soveral LF, Korczaguin GG, Schmidt PS, Nunes IS, Fernandes C, Zárate-Bladés CR. Immunological mechanisms of fecal microbiota transplantation in recurrent Clostridioides difficile infection. World J Gastroenterol 2022; 28(33): 4762-4772 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i33/4762.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i33.4762 |
