Publication Name	World Journal of Clinical Cases
Manuscript ID	76531
Country	China

Received	2022-03-21 11:27
Peer-Review Started	2022-03-21 11:29
First Decision by Editorial Office Director	2022-05-01 02:04
Return for Revision	2022-05-01 13:01
Revised	2022-05-14 06:57
Publication Fee Transferred
Second Decision by Editor	2022-07-13 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-07-17 23:09
Articles in Press	2022-07-17 23:09
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-08-02 02:13
Publish the Manuscript Online	2022-08-16 01:35

ISSN	2307-8960 (online)
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Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	Pyroptosis-related genes play a significant role in the prognosis of gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Shi-Hao Guan, Xin-Yu Wang, Ping Shang, Qian-Cheng Du, Ming-Zhi Li, Xiao Xing and Bin Yan
Funding Agency and Grant Number
Corresponding Author	Bin Yan, PhD, Chief Doctor, Professor, Department of General Surgery, the Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, No. 1158 Gongyuan East Road, Shanghai 201700, China. yanbin202203@163.com
Key Words	Gastric cancer; Pyroptosis; Gene signature; Overall survival
Core Tip	This study aims to evaluate the expression of pyroptosis-related genes in gastric cancer (GC) and its correlation with prognosis. Based on 63 pyroptosis differentially expressed genes, 5 gene signature were constructed and all GC patients were classified into two risk groups. Kaplan-Meier survival curve showed that the overall survival (OS) of patients in the high-risk group was significantly lower than that of the low-risk group. Multivariate Cox regression analyses showed that the risk score was an independent risk factor for OS. The immune function and immune cell scores of the high-risk group were generally higher than those of the low-risk group. Similar results were obtained in external validation.
Publish Date	2022-08-16 01:35
Citation	Guan SH, Wang XY, Shang P, Du QC, Li MZ, Xing X, Yan B. Pyroptosis-related genes play a significant role in the prognosis of gastric cancer. World J Clin Cases 2022; 10(24): 8490-8505
URL	https://www.wjgnet.com/2307-8960/full/v10/i24/8490.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i24.8490

Full Article (PDF)	WJCC-10-8490.pdf
Full Article (Word)	WJCC-10-8490.docx
Manuscript File	76531_Auto_Edited-YJM-LS.docx
Answering Reviewers	76531-Answering reviewers.pdf
Audio Core Tip	76531-Audio core tip.m4a
Biostatistics Review Certificate	76531-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	76531-Conflict-of-interest statement.pdf
Copyright License Agreement	76531-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	76531-Language certificate.pdf
Peer-review Report	76531-Peer-review(s).pdf
Scientific Editor Work List	76531-Scientific editor work list.pdf
CrossCheck Report	76531-CrossCheck report.pdf