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9/23/2022 10:51:25 AM | Browse: 198 | Download: 513
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Received |
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2022-03-28 08:30 |
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Peer-Review Started |
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2022-03-28 08:33 |
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To Make the First Decision |
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Return for Revision |
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2022-06-11 04:43 |
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Revised |
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2022-06-20 09:50 |
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Second Decision |
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2022-08-29 04:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-08-30 22:45 |
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Articles in Press |
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2022-08-30 22:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-08-16 13:21 |
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Typeset the Manuscript |
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2022-09-22 03:04 |
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Publish the Manuscript Online |
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2022-09-23 09:45 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Overexpression of GATA binding protein 4 and myocyte enhancer factor 2C induces differentiation of mesenchymal stem cells into cardiac-like cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Syeda Saima Razzaq, Irfan Khan, Nadia Naeem, Asmat Salim, Sumreen Begum and Kanwal Haneef |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Higher Education Commission (HEC), Pakistan Scholarship for Ph.D. Studies to Razzaq SS |
520-148390-2BS6-011 |
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| Corresponding Author |
Kanwal Haneef, PhD, Assistant Professor, Dr. Zafar H. Zaidi Center for Proteomics, University of Karachi, University Road, Karachi 75270, Pakistan. k.haneef@uok.edu.pk |
| Key Words |
Heart disease; GATA binding protein 4; Myocyte enhancer factor 2C; Transcription factors; Differentiation; Human umbilical cord-mesenchymal stem cells |
| Core Tip |
Transcription factors have great potential to direct cell fate decisions during embryonic development. In this study, we investigated the overexpression of cardiac transcription factors in human umbilical cord mesenchymal stem cells to enhance their differentiation into cardiac-like cells. The synergistic effect of GATA binding protein 4 and myocyte enhancer factor 2C transcription factors increased the expression of cardiac genes and proteins. The results of this study will aid in the development of new therapeutic strategies aimed at curing heart diseases. |
| Publish Date |
2022-09-23 09:45 |
| Citation |
Razzaq SS, Khan I, Naeem N, Salim A, Begum S, Haneef K. Overexpression of GATA binding protein 4 and myocyte enhancer factor 2C induces differentiation of mesenchymal stem cells into cardiac-like cells. World J Stem Cells 2022; 14(9): 700-713 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i9/700.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i9.700 |
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