Publication Name	World Journal of Stem Cells
Manuscript ID	77481
Country	China

Received	2022-05-02 12:17
Peer-Review Started	2022-05-02 12:20
To Make the First Decision
Return for Revision	2022-06-11 04:34
Revised	2022-06-24 12:05
Second Decision	2022-08-08 03:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-18 00:20
Articles in Press	2022-08-18 00:20
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-08-03 20:38
Typeset the Manuscript	2022-09-22 00:31
Publish the Manuscript Online	2022-09-23 09:45

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxia
Manuscript Source	Unsolicited Manuscript
All Author List	Xu-Dong Feng, Jia-Hang Zhou, Jun-Yao Chen, Bing Feng, Rui-Tian Hu, Jian Wu, Qiao-Ling Pan, Jin-Feng Yang, Jiong Yu and Hong-Cui Cao
Funding Agency and Grant Number	Funding Agency Grant Number Stem Cell and Translational Research from National Key Research and Development Program of China 2020YFA0113003 National Natural Science Foundation of China 81971756
Corresponding Author	Hong-Cui Cao, Doctor, Chief Doctor, State Key Laboratory for The Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. hccao@zju.edu.cn
Key Words	Human placenta-derived mesenchymal stem cell; Hypoxia; Long non-coding RNAs; Proliferation; Mesenchymal stem cell
Core Tip	This study revealed that the specific expression and co-expressed profiles of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in human placenta-derived mesenchymal stem cells (hP-MSCs) under hypoxia by RNA sequencing assays. Through the performance of a series of systemic bioinformatic analyses of these differentially expressed lncRNAs and mRNAs, the hypoxia-responsive lncRNA SNHG16 that may play a role in proliferation was screened out. Furthermore, through the use of molecular biology experiments, SNHG16 was found to affect hP-MSCs proliferation rates and cell cycle progression by activating PI3K/AKT pathway and upregulating the expression of the key cell cycle regulators.
Publish Date	2022-09-23 09:45
Citation	Feng XD, Zhou JH, Chen JY, Feng B, Hu RT, Wu J, Pan QL, Yang JF, Yu J, Cao HC. Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxia. World J Stem Cells 2022; 14(9): 714-728
URL	https://www.wjgnet.com/1948-0210/full/v14/i9/714.htm
DOI	https://dx.doi.org/10.4252/wjsc.v14.i9.714

Full Article (PDF)	WJSC-14-714.pdf
Full Article (Word)	WJSC-14-714.docx
Manuscript File	77481_Auto_Edited-JRF-Filipodia CL-LS.docx
Answering Reviewers	77481-Answering reviewers.pdf
Audio Core Tip	77481-Audio core tip.m4a
Biostatistics Review Certificate	77481-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	77481-Conflict-of-interest statement.pdf
Copyright License Agreement	77481-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	77481-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	77481-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	77481-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	77481-Language certificate.pdf
Supplementary Material	77481-Supplementary material.pdf
Peer-review Report	77481-Peer-review(s).pdf
Scientific Misconduct Check	77481-Bing-Fan JR-2.png
Scientific Editor Work List	77481-Scientific editor work list.pdf