| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxia
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xu-Dong Feng, Jia-Hang Zhou, Jun-Yao Chen, Bing Feng, Rui-Tian Hu, Jian Wu, Qiao-Ling Pan, Jin-Feng Yang, Jiong Yu and Hong-Cui Cao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Stem Cell and Translational Research from National Key Research and Development Program of China |
2020YFA0113003 |
| National Natural Science Foundation of China |
81971756 |
|
| Corresponding Author |
Hong-Cui Cao, Doctor, Chief Doctor, State Key Laboratory for The Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. hccao@zju.edu.cn |
| Key Words |
Human placenta-derived mesenchymal stem cell; Hypoxia; Long non-coding RNAs; Proliferation; Mesenchymal stem cell |
| Core Tip |
This study revealed that the specific expression and co-expressed profiles of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in human placenta-derived mesenchymal stem cells (hP-MSCs) under hypoxia by RNA sequencing assays. Through the performance of a series of systemic bioinformatic analyses of these differentially expressed lncRNAs and mRNAs, the hypoxia-responsive lncRNA SNHG16 that may play a role in proliferation was screened out. Furthermore, through the use of molecular biology experiments, SNHG16 was found to affect hP-MSCs proliferation rates and cell cycle progression by activating PI3K/AKT pathway and upregulating the expression of the key cell cycle regulators. |
| Publish Date |
2022-09-23 09:45 |
| Citation |
Feng XD, Zhou JH, Chen JY, Feng B, Hu RT, Wu J, Pan QL, Yang JF, Yu J, Cao HC. Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxia. World J Stem Cells 2022; 14(9): 714-728 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i9/714.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i9.714 |
