Publication Name	World Journal of Gastroenterology
Manuscript ID	77593
Country	China

Received	2022-05-26 09:26
Peer-Review Started	2022-05-26 09:27
To Make the First Decision
Return for Revision	2022-06-19 00:37
Revised	2022-06-28 15:15
Second Decision	2022-07-22 07:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-07-25 00:43
Articles in Press	2022-07-25 00:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-08-10 05:53
Publish the Manuscript Online	2022-08-16 11:59

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Duodenal-jejunal bypass increases intraduodenal bile acids and upregulates duodenal SIRT1 expression in high-fat diet and streptozotocin-induced diabetic rats
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Feng Han, Shao-Zhuang Liu, Xiang Zhang, Meng Wei, Xin Huang and Wen-Bin Yu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81600617, 81700708, 81702647, 82100853 the Natural Science Foundation of Shandong Province ZR2020MH246, ZR2021LZL003, ZR2021QH028
Corresponding Author	Wen-Bin Yu, MD, PhD, Chief Doctor, Professor, Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 West Wenhua Road, Jinan 250012, Shandong Province, China. wenbin_yu2003@163.com
Key Words	Duodenal-jejunal bypass; Diabetes mellitus; Bile acids; Sirtuin 1; Duodenum; High-fat diet
Core Tip	The intrinsic mechanisms of diabetes remission after duodenal-jejunal bypass (DJB) surgery are complicated. Duodenal SIRT1 is a novel therapeutic target for diabetes, and increased duodenal SIRT1 is linked to improved hepatic insulin sensitivity and decreased hepatic glucose output. The animal study demonstrated that DJB increased intraduodenal bile acid (BA) levels, activated the BA signaling pathway, and upregulated SIRT1 expression in the duodenal mucosa. Our cell experiments proved that farnesoid X receptor and Takeda G-protein-coupled receptor 5 activation increased SIRT1 expression in rat small intestine epithelial cells, indicating that increased intraluminal BAs and activation of BA receptors contributed to increased duodenal SIRT1 after DJB.
Publish Date	2022-08-16 11:59
Citation	Han HF, Liu SZ, Zhang X, Wei M, Huang X, Yu WB. Duodenal-jejunal bypass increases intraduodenal bile acids and upregulates duodenal SIRT1 expression in high-fat diet and streptozotocin-induced diabetic rats. World J Gastroenterol 2022; 28(31): 4338-4350
URL	https://www.wjgnet.com/1007-9327/full/v28/i31/4338.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i31.4338

Full Article (PDF)	WJG-28-4338.pdf
Full Article (Word)	WJG-28-4338.docx
The ARRIVE Guidelines	77593-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	77593_Auto_Edited-LS.docx
Answering Reviewers	77593-Answering reviewers.pdf
Audio Core Tip	77593-Audio core tip.wav
Biostatistics Review Certificate	77593-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	77593-Conflict-of-interest statement.pdf
Copyright License Agreement	77593-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	77593-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	77593-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	77593-Language certificate.pdf
Peer-review Report	77593-Peer-review(s).pdf
Scientific Misconduct Check	77593-Bing-Wang JJ-2.png
Scientific Editor Work List	77593-Scientific editor work list.pdf