Publication Name	World Journal of Diabetes
Manuscript ID	77975
Country	Italy

Received	2022-05-30 19:34
Peer-Review Started	2022-05-30 19:37
To Make the First Decision
Return for Revision	2022-08-07 18:08
Revised	2022-08-17 09:24
Second Decision	2022-10-11 03:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-10-11 17:47
Articles in Press	2022-10-11 17:47
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-10-02 21:41
Typeset the Manuscript	2022-11-02 13:27
Publish the Manuscript Online	2022-11-11 10:05

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Type 2 diabetes and bone fragility in children and adults
Manuscript Source	Invited Manuscript
All Author List	Maria Felicia Faienza, Paola Pontrelli and Giacomina Brunetti
Funding Agency and Grant Number
Corresponding Author	Giacomina Brunetti, PhD, Associate Professor, Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, Via Orabona, 4, Bari 70125, Italy. giacomina.brunetti@uniba.it
Key Words	Type 2 diabetes; Bone remodeling; Cytokines; Bone fragility; Bone mineral density; Chronic kidney disease
Core Tip	Type 2 diabetes (T2D) patients show increased susceptibility to bone fractures, despite their bone mineral density being normal or increased, leading to difficult identification for clinicians. The prevalence of T2D in adolescents and young adults is increasing alarmingly. Different researchers highlighted the mechanisms leading to bone fragility, and different critical altered pathways have been identified and studied. In this review, we described the different metabolic pathways responsible for bone fragility in patients with T2D. They can be useful for its management, although further studies are needed to deepen our understanding of the mechanisms underlying bone fragility in T2D.
Publish Date	2022-11-11 10:05
Citation	Faienza MF, Pontrelli P, Brunetti G. Type 2 diabetes and bone fragility in children and adults. World J Diabetes 2022; 13(11): 900-911
URL	https://www.wjgnet.com/1948-9358/full/v13/i11/900.htm
DOI	https://dx.doi.org/10.4239/wjd.v13.i11.900

Full Article (PDF)	WJD-13-900.pdf
Full Article (Word)	WJD-13-900.docx
Manuscript File	77975_Auto_Edited-LM.docx
Answering Reviewers	77975-Answering reviewers.pdf
Audio Core Tip	77975-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	77975-Conflict-of-interest statement.pdf
Copyright License Agreement	77975-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	77975-Language certificate.pdf
Peer-review Report	77975-Peer-review(s).pdf
Scientific Misconduct Check	77975-Bing-Wang JJ-2.png
Scientific Editor Work List	77975-Scientific editor work list.pdf