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3/23/2023 8:54:01 AM | Browse: 163 | Download: 423
Publication Name World Journal of Stem Cells
Manuscript ID 78294
Country/Territory China
Received
2022-06-30 14:07
Peer-Review Started
2022-06-30 14:10
To Make the First Decision
Return for Revision
2022-12-30 05:44
Revised
2023-01-06 11:06
Second Decision
2023-02-08 03:37
Accepted by Journal Editor-in-Chief
2023-02-09 01:57
Accepted by Company Editor-in-Chief
2023-02-16 19:19
Articles in Press
2023-02-16 19:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-03-20 01:55
Publish the Manuscript Online
2023-03-23 08:29
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title Mammalian Ste20-like kinase 1 inhibition as a cellular mediator of anoikis in mouse bone marrow mesenchymal stem cells
Manuscript Source Unsolicited Manuscript
All Author List Tao Zhang, Qian Zhang and Wan-Cheng Yu
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Shandong Province of China ZR2021QH179
Natural Science Foundation of Shandong Province of China ZR2020MH014
Natural Science Foundation of Shandong Province of China ZR2021MH182
Corresponding Author Wan-Cheng Yu, Doctor, MD, Surgeon, Department of Cardiovascular Surgery, Shandong Provincial Hospital, No. 324 Jingwu Weiqi Road, Jinan 250062, Shandong Province, China. yuwancheng123@126.com
Key Words Mouse bone marrow mesenchymal stem cell; Mammalian sterile 20-like kinase 1; Anoikis; Integrin; Autophagy; Reactive oxygen species
Core Tip In isolated mouse bone marrow mesenchymal stem cell (mBMSCs), Mammalian sterile 20-like kinase 1 (Mst1) inhibition could ameliorate not only autophagy formation but also upregulate integrin (ITG) α5β1 expression (but not ITGα4, ITGαv, or ITGβ3). In addition, Mst1 inhibition-induced autophagy could scavenge the excessive production of ITGα5β1-triggered ROS. Therefore, Mst1 inhibition-based infusion may improve the survival of MSCs, thereby serving as an ideal candidate for clinical transplantation in pulmonary arterial hypertension.
Publish Date 2023-03-23 08:29
Citation Zhang T, Zhang Q, Yu WC. Mammalian Ste20-like kinase 1 inhibition as a cellular mediator of anoikis in mouse bone marrow mesenchymal stem cells. World J Stem Cells 2023; 15(3): 90-104
URL https://www.wjgnet.com/1948-0210/full/v15/i3/90.htm
DOI https://dx.doi.org/10.4252/wjsc.v15.i3.90
Full Article (PDF) WJSC-15-90.pdf
Full Article (Word) WJSC-15-90.docx
Manuscript File 78294_Auto_Edited-LM.docx
Answering Reviewers 78294-Answering reviewers.pdf
Audio Core Tip 78294-Audio core tip.MP3
Biostatistics Review Certificate 78294-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 78294-Conflict-of-interest statement.pdf
Copyright License Agreement 78294-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 78294-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 78294-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 78294-Language certificate.pdf
Supplementary Material 78294-Supplementarymaterial.pdf
Peer-review Report 78294-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 78294-Institutional animal care and use committee statement.pdf
Scientific Misconduct Check 78294-Bing-Liu GL-2.png
Scientific Editor Work List 78294-Scientific editor work list.pdf