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9/9/2022 1:12:42 PM | Browse: 48 | Download: 49
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 78296
Country/Territory United States
Received
2022-06-18 18:39
Peer-Review Started
2022-06-18 18:42
To Make the First Decision
Return for Revision
2022-07-19 16:52
Revised
2022-07-28 13:32
Second Decision
2022-08-08 03:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-08-17 23:47
Articles in Press
2022-08-17 23:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-08-26 01:37
Publish the Manuscript Online
2022-09-09 12:48
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Letter to the Editor
Article Title Nutrition deprivation affects the cytotoxic effect of CD8 T cells in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Chun-Ye Zhang, Shuai Liu and Ming Yang
Funding Agency and Grant Number
Corresponding Author Ming Yang, DVM, PhD, Postdoctoral Fellow, Department of Surgery, University of Missouri, Room 2203, NexGen Precision Building, 1030 Hitt Street, Columbia, MO 65211, United States. yangmin@health.missouri.edu
Key Words Hepatocellular carcinoma; Metabolism; Amino acids; Tumor microenvironment; T cell function
Core Tip Immunotherapy is one of the most powerful tools for patients with unresectable hepatocellular carcinoma. CD8+ T cells are a major immune component in the tumor microenvironment with cytotoxic effects against tumor cells. However, these CD8+ T cells commonly display an exhaustion phenotype with high expression of immune checkpoints such as programmed cell death protein 1, producing less anti-tumor proteins and cytokines, such as perforin and granzyme B. Here, we show that the roles of amino acids such as glutamine in T cell activation and function are dependent on tumor types and nutrients in the tumor microenvironment. Overall, nutrient metabolism reprogramming in the tumor microenvironment plays a pivotal role in both tumor growth and immune response.
Publish Date 2022-09-09 12:48
Citation Zhang CY, Liu S, Yang M. Nutrition deprivation affects the cytotoxic effect of CD8 T cells in hepatocellular carcinoma. World J Gastrointest Oncol 2022; 14(9): 1887-1891
URL https://www.wjgnet.com/1948-5204/full/v14/i9/1887.htm
DOI https://dx.doi.org/10.4251/wjgo.v14.i9.1887
Full Article (PDF) WJGO-14-1887.pdf
Full Article (Word) WJGO-14-1887.docx
Manuscript File 78296_Auto_Edited-LS.docx
Answering Reviewers 78296-Answering reviewers.pdf
Audio Core Tip 78296-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 78296-Conflict-of-interest statement.pdf
Copyright License Agreement 78296-Copyright license agreement.pdf
Peer-review Report 78296-Peer-review(s).pdf
Scientific Misconduct Check 78296-Bing-Wang LL-2.jpg
Scientific Editor Work List 78296-Scientific editor work list.pdf