BPG is committed to discovery and dissemination of knowledge
Featured Articles
12/12/2022 8:05:58 AM | Browse: 265 | Download: 907
 |
Received |
|
2022-07-14 02:13 |
|
Peer-Review Started |
|
2022-07-14 02:16 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2022-09-26 09:21 |
|
Revised |
|
2022-10-17 08:03 |
|
Second Decision |
|
2022-11-23 03:37 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2022-11-23 06:57 |
|
Articles in Press |
|
2022-11-23 06:57 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
2022-11-10 21:43 |
|
Typeset the Manuscript |
|
2022-12-05 04:31 |
|
Publish the Manuscript Online |
|
2022-12-12 06:36 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
N-myc downstream regulated gene 1 inhibition of tumor progression in Caco2 cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Xiao He, Hong Shen, Yu-Zhu Ji, Hai-Rong Hua, Yu Zhu, Xiang-Fei Zeng, Fang Wang and Kai-Xin Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81260361 |
| Incubation Project of Mianyang Central Hospital |
2020FH05 |
|
| Corresponding Author |
Kai-Xin Wang, MD, Associate Chief Physician, Department of Pathology, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), No. 89 Taoyuan Road, Nanshan District, Shenzhen 518052, Guangdong Province, China. 313683968@qq.com |
| Key Words |
N-myc downstream regulated gene 1; Caco2; Colorectal cancer; Tumor progression; CRISPR/Cas9; Lentivirus infection |
| Core Tip |
This study investigated the molecular functions of N-myc downstream regulated gene 1 (NDRG1) in the process of colorectal cancer (CRC) migration through stable over-expression or knockout of NDRG1 in the Caco2 CRC cell line. Our results showed that NDRG1 over-expression arrested the cell cycle at the G1/S phase, while its knock-out significantly increased the number of G2 phase cells. Altogether, our results highlight the fact that NDRG1 inhibits tumor progression in Caco2 cells which may provide a novel diagnostic or therapeutic tool in inhibiting the migration of CRC. |
| Publish Date |
2022-12-12 06:36 |
| Citation |
He YX, Shen H, Ji YZ, Hua HR, Zhu Y, Zeng XF, Wang F, Wang KX. N-myc downstream regulated gene 1 inhibition of tumor progression in Caco2 cells. World J Gastrointest Oncol 2022; 2022; 14(12): 2313-2328 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i12/2313.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i12.2313 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
