Publication Name	World Journal of Hepatology
Manuscript ID	78461
Country	United States

Received	2022-06-27 17:52
Peer-Review Started	2022-06-27 17:56
To Make the First Decision
Return for Revision	2022-07-25 18:38
Revised	2022-08-02 00:42
Second Decision	2023-01-13 03:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-01-13 20:27
Articles in Press	2023-01-13 20:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-01-19 10:16
Publish the Manuscript Online	2023-02-24 13:35

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical and Translational Research
Article Title	Progressive changes in platelet counts and Fib-4 scores precede the diagnosis of advanced fibrosis in NASH patients
Manuscript Source	Unsolicited Manuscript
All Author List	Michael K Zijlstra, Anuhya Gampa, Nora Joseph, Amnon Sonnenberg and Claus J Fimmel
Funding Agency and Grant Number
Corresponding Author	Claus J Fimmel, MD, Professor, Division of Gastroenterology, Department of Internal Medicine, NorthShore University Health System, Evanston Hospital 2650 Ridge Avenue Burch Building, Room 103A, Evanston, IL 60201, United States. clausfimmel@att.net
Key Words	Non-alcoholic fatty liver disease; Liver fibrosis; cirrhosis; Prediction; Liver biopsy; Magnetic resonance elastography
Core Tip	Our study is based on the well-known phenomenon of declining platelet counts in patients who develop cirrhosis, including those with underlying non-alcoholic fatty liver disease (NASH). This phenomenon has resulted in several recent publications using large health registries to show that progressive changes in non-invasive fibrosis scores preceded the ICD 9-based diagnoses of cirrhosis. These studies raised the issue of “predictability” of cirrhosis development. Our analysis extends these studies by examining a smaller, well-defined NASH patient population. Unlike previous studies, we included ALL fibrosis stages, provided that patients had undergone definitive staging by liver biopsy or magnetic resonance elastography. Our data unequivocally confirm that progressive thrombocytopenia and an increase in the Fib-4 scores precedes the diagnosis of cirrhosis. Moreover, the kinetics of the platelet drop add to the prediction of cirrhosis, suggesting that the time-dependent decrease in platelet counts may have true predictive power.
Publish Date	2023-02-24 13:35
Citation	Zijlstra MK, Gampa A, Joseph N, Sonnenberg A, Fimmel CJ. Progressive changes in platelet counts and Fib-4 scores precede the diagnosis of advanced fibrosis in NASH patients. World J Hepatol 2022; 15(2): 225-236
URL	https://www.wjgnet.com/1948-5182/full/v15/i2/225.htm
DOI	https://dx.doi.org/10.4254/wjh.v15.i2.225

Full Article (PDF)	WJH-15-225.pdf
Full Article (Word)	WJH-15-225.docx
Manuscript File	78461_Auto_Edited-LM.docx
Answering Reviewers	78461-Answering reviewers.pdf
Audio Core Tip	78461-Audio core tip.wav
Clinical Trial Registration Statement	78461-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	78461-Conflict-of-interest statement.pdf
Copyright License Agreement	78461-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	78461-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	78461-Institutional review board statement.pdf
Supplementary Material	78461-Supplementary material.pdf
Peer-review Report	78461-Peer-review(s).pdf
Scientific Misconduct Check	78461-Bing-Liu JH-2.jpg
Scientific Misconduct Check	78461-CrossCheck.jpg
Scientific Editor Work List	78461-Scientific editor work list.pdf
CrossCheck Report	78461-CrossCheck report.pdf