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12/12/2022 8:05:58 AM | Browse: 230 | Download: 812
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Received |
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2022-06-29 06:41 |
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Peer-Review Started |
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2022-06-29 06:45 |
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To Make the First Decision |
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Return for Revision |
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2022-08-08 03:46 |
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Revised |
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2022-08-31 08:56 |
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Second Decision |
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2022-11-04 03:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-11-04 19:45 |
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Articles in Press |
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2022-11-04 19:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-10-13 09:08 |
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Typeset the Manuscript |
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2022-12-04 07:33 |
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Publish the Manuscript Online |
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2022-12-12 06:36 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Anti-silencing function 1B knockdown suppresses the malignant phenotype of colorectal cancer by inactivating the phosphatidylinositol 3-kinase/AKT pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gen-Hua Yu, Xu-Feng Gong, Ying-Ying Peng and Jun Qian |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Huzhou Science and Technology Bureau Foundation |
2018GY09 |
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| Corresponding Author |
Jun Qian, MD, PhD, Professor, Surgeon, Department of Colorectal Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), No. 1 Banshan East Road, Gongshu District, Hangzhou 310022, Zhejiang Province, China. qianj1973@aliyun.com |
| Key Words |
Colorectal cancer; Anti-silencing function 1B; Phosphatidylinositol 3-kinase/AKT; Stemness; Epithelial mesenchymal transition |
| Core Tip |
Anti-silencing function 1B (ASF1B) expression was increased in colorectal cancer (CRC) tissues and cells, and was negatively associated with prognosis of CRC patients. Functionally, ASF1B knockdown repressed the malignant behaviors of CRC cells in vitro and tumorigenesis in vivo, therefore having potential for CRC treatment. Moreover, our findings showed that ASF1B down-regulation suppressed the malignant behaviors of CRC cells by inactivating the PI3K/AKT pathway. |
| Publish Date |
2022-12-12 06:36 |
| Citation |
Yu GH, Gong XF, Peng YY, Qian J. Anti-silencing function 1B knockdown suppresses the malignant phenotype of colorectal cancer by inactivating the phosphatidylinositol 3-kinase/AKT pathway. World J Gastrointest Oncol 2022; 14(12): 2353-2366 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i12/2353.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i12.2353 |
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