Publication Name	World Journal of Clinical Cases
Manuscript ID	78885
Country	China

Received	2022-07-20 05:13
Peer-Review Started	2022-07-20 05:15
To Make the First Decision
Return for Revision	2022-11-08 05:48
Revised	2022-11-20 12:11
Second Decision	2022-12-07 03:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-12-08 00:19
Articles in Press	2022-12-08 00:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-12-13 03:11
Publish the Manuscript Online	2022-12-26 18:23

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Liver injury in COVID-19: Holds ferritinophagy-mediated ferroptosis accountable
Manuscript Source	Invited Manuscript
All Author List	Feng-Ju Jia and Jing Han
Funding Agency and Grant Number	Funding Agency Grant Number Shandong Provincial Natural Science Foundation ZR2020QC088
Corresponding Author	Feng-Ju Jia, PhD, Doctor, Doctor, School of Nursing, Qingdao University, No. 308 Ningxia Road, Qingdao 266071, Shandong Province, China. jiafegngjv@163.com
Key Words	COVID-19; Liver injury; Ferritinophagy; Ferroptosis; Iron; SARS-CoV-2
Core Tip	Liver injury in patients with coronavirus disease 2019 (COVID-19) has progressively emerged, yet the exact pathophysiological mechanisms to explain liver pathogenicity is presently not fully understood. We hypothesize that cytokine storms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may promote hyper-ferritinemia, which can further aggravate inflammation. Elevated ferritin levels can trigger nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy, which leads to iron elevation, and ferroptosis. NCOA4-mediated ferritinophagy can be targeted to limit the ferroptosis and, therefore, prevent liver damage and disease severity in patients with COVID-19.
Publish Date	2022-12-26 18:23
Citation	Jia FJ, Han J. Liver injury in COVID-19: Holds ferritinophagy-mediated ferroptosis accountable. World J Clin Cases 2022; 10(36): 13148-13156
URL	https://www.wjgnet.com/2307-8960/full/v10/i36/13148.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i36.13148

Full Article (PDF)	WJCC-10-13148.pdf
Full Article (Word)	WJCC-10-13148.docx
Manuscript File	78885_Auto_Edited-LJH-JLW.docx
Answering Reviewers	78885-Answering reviewers.pdf
Audio Core Tip	78885-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	78885-Conflict-of-interest statement.pdf
Copyright License Agreement	78885-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	78885-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	78885-Language certificate.pdf
Supplementary Material	78885-Supplementary material.pdf
Peer-review Report	78885-Peer-review(s).pdf
Scientific Misconduct Check	78885-Bing-Liu JH-2.jpg
Scientific Misconduct Check	78885-CrossCheck.jpg
Scientific Editor Work List	78885-Scientific editor work list.pdf
CrossCheck Report	78885-CrossCheck report.pdf