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10/20/2022 7:11:42 AM | Browse: 177 | Download: 557
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Received |
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2022-07-26 22:56 |
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Peer-Review Started |
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2022-07-26 22:59 |
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To Make the First Decision |
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Return for Revision |
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2022-08-18 04:53 |
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Revised |
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2022-08-25 14:13 |
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Second Decision |
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2022-09-16 03:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-09-16 16:22 |
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Articles in Press |
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2022-09-16 16:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-10-13 07:13 |
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Publish the Manuscript Online |
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2022-10-20 06:46 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Somatic mutations in FAT cadherin family members constitute an underrecognized subtype of colorectal adenocarcinoma with unique clinicopathologic features
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Liang-Li Wang, Wei Zheng, Xiu-Li Liu and Feng Yin |
| Funding Agency and Grant Number |
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| Corresponding Author |
Feng Yin, MD, PhD, Assistant Professor, Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, One Hospital Drive, Columbia, MO 65212, United States. fengyin@health.missouri.edu |
| Key Words |
FAT cadherin family genes; Colorectal adenocarcinoma; Clinicopathologic features; Prognosis; The Cancer Genome Atlas |
| Core Tip |
Colorectal carcinoma (CRC) is the third most common cancer and the second leading cause of cancer-related deaths worldwide. In this study, we aimed to characterize the clinicopathologic features of CRC patients with somatic mutations in FAT cadherin family members. CRC cases have frequent mutations in FAT family genes. The FAT-mutated CRC subtype is more commonly located on the right side of the colon and shows favorable clinicopathologic features, including a lower rate of positive lymph nodes and a lower rate of metastasis to another site or organ, suggesting that the FAT somatic mutation is a potentially independent prognostic factor in CRC. |
| Publish Date |
2022-10-20 06:46 |
| Citation |
Wang LL, Zheng W, Liu XL, Yin F. Somatic mutations in FAT cadherin family members constitute an underrecognized subtype of colorectal adenocarcinoma with unique clinicopathologic features. World J Clin Oncol 2022; 13(10): 779-788 |
| URL |
https://www.wjgnet.com/2218-4333/full/v13/i10/779.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v13.i10.779 |
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