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12/12/2022 8:05:58 AM | Browse: 217 | Download: 611
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Received |
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2022-08-11 03:50 |
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Peer-Review Started |
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2022-08-11 03:53 |
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To Make the First Decision |
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Return for Revision |
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2022-10-06 01:20 |
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Revised |
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2022-10-17 04:13 |
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Second Decision |
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2022-11-10 03:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-11-16 17:32 |
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Articles in Press |
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2022-11-16 17:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-12-05 03:40 |
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Publish the Manuscript Online |
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2022-12-12 06:36 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Inhibition of bromodomain-containing protein 4 enhances the migration of esophageal squamous cell carcinoma cells by inducing cell autophagy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Qian Yang, Rui Liang, Man-Qi Gao, Yu-Zhen Liu, Bo Qi and Bao-Sheng Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Health Commission of Henan Province of China |
SBGJ202102188 |
| Key Project of Science and Technology of Xinxiang |
GG2020027 |
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| Corresponding Author |
Bao-Sheng Zhao, BMed, Chief Physician, Professor, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui 453100, Henan Province, China. drbszhao@xxmu.edu.cn |
| Key Words |
JQ1; Bromodomain-containing protein 4; Cell migration; Cell autophagy; Epithelial-mesenchymal transition; Esophageal squamous cell carcinoma |
| Core Tip |
It has been demonstrated that bromodomain-containing protein 4 (BRD4) as a transcriptional regulator promotes tumor development. Thus, targeting of BRD4 has recently emerged as a promising anti-cancer therapeutic strategy. We present here that BRD4 inhibition suppresses esophageal squamous cell carcinoma (ESCC) cell proliferation, but promotes ESCC cell migration by induction of autophagy, which further facilities epithelial-mesenchymal transition process. Our study implies that the migration-promoting effect should be carefully considered when clinical targeting BRD4 as anti-cancer approach and combination with autophagy inhibitor might be a new therapeutic strategy to avoid the deleterious role of BRD4-targeted strategies. |
| Publish Date |
2022-12-12 06:36 |
| Citation |
Yang WQ, Liang R, Gao MQ, Liu YZ, Qi B, Zhao BS. Inhibition of bromodomain-containing protein 4 enhances the migration of esophageal squamous cell carcinoma cells by inducing cell autophagy. World J Gastrointest Oncol 2022; 14(12): 2340-2352 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i12/2340.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i12.2340 |
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