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11/21/2022 9:21:57 AM | Browse: 22 | Download: 23
Publication Name World Journal of Clinical Oncology
Manuscript ID 79109
Country/Territory Japan
Received
2022-08-03 18:37
Peer-Review Started
2022-08-03 18:40
To Make the First Decision
Return for Revision
2022-08-30 14:41
Revised
2022-09-12 07:34
Second Decision
2022-10-18 03:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-10-18 17:08
Articles in Press
2022-10-18 17:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-11-08 03:26
Publish the Manuscript Online
2022-11-21 04:25
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors
Manuscript Source Unsolicited Manuscript
All Author List Winn Aung, Atsushi B Tsuji, Kenjiro Hanaoka and Tatsuya Higashi
Funding Agency and Grant Number
Funding Agency Grant Number
Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science 21K07740
Corresponding Author Winn Aung, MBBS, PhD, Senior Researcher, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. winn.aung@qst.go.jp
Key Words Photodynamic therapy; Near-infrared; Photosensitizer; Folate receptor; Fluorescence; Cancer
Core Tip Photodynamic therapy (PDT) is a minimally invasive cancer therapy and photosensitizers (PS) with optimal properties are crucial for enhancing the efficacy of PDT. We evaluated the therapeutic efficacy of a folate receptor (FR)-targeted, near-infrared (NIR)-sensitive PS (FolateSiR-1). FolateSiR-1 showed FR specificity in vitro and in vivo and functions as a tumor-damaging PS by inducing necrosis, apoptosis, and cell growth inhibition upon activation with NIR light. Our findings suggest that FolateSiR-1 is effective in FR-targeted NIR-PDT with low side effects and has potential for presenting new and effective treatment options for FR-overexpressing tumors.
Publish Date 2022-11-21 04:25
Citation Aung W, Tsuji AB, Hanaoka K, Higashi T. Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors. World J Clin Oncol 2022; 13(11): 880-895
URL https://www.wjgnet.com/2218-4333/full/v13/i11/880.htm
DOI https://dx.doi.org/10.5306/wjco.v13.i11.880
Full Article (PDF) WJCO-13-880.pdf
Full Article (Word) WJCO-13-880.docx
Manuscript File 79109_Auto_Edited-LM.docx
Answering Reviewers 79109-Answering reviewers.pdf
Audio Core Tip 79109-Audio core tip.m4a
Biostatistics Review Certificate 79109-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 79109-Conflict-of-interest statement.pdf
Copyright License Agreement 79109-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 79109-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 79109-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 79109-Language certificate.pdf
Peer-review Report 79109-Peer-review(s).pdf
Scientific Misconduct Check 79109-CrossCheck.png
Scientific Misconduct Check 79109-Bing-Gong ZM-2.png
Scientific Editor Work List 79109-Scientific editor work list.pdf