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11/21/2022 9:21:57 AM | Browse: 27 | Download: 26
Publication Name World Journal of Clinical Oncology
Manuscript ID 79141
Country/Territory Brazil
Received
2022-08-06 01:39
Peer-Review Started
2022-08-06 01:42
To Make the First Decision
Return for Revision
2022-09-05 09:42
Revised
2022-09-20 02:59
Second Decision
2022-10-11 03:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-10-11 18:33
Articles in Press
2022-10-11 18:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-10-25 17:02
Typeset the Manuscript
2022-11-16 06:37
Publish the Manuscript Online
2022-11-21 04:25
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Influence of Helicobacter pylori oncoprotein CagA in gastric cancer: A critical-reflective analysis
Manuscript Source Invited Manuscript
All Author List Fabrício Freire de Melo, Hanna Santos Marques, Samuel Luca Rocha Pinheiro, Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Kádima Nayara Teixeira, Cláudio Lima Souza and Márcio Vasconcelos Oliveira
Funding Agency and Grant Number
Funding Agency Grant Number
National Council for Scientific and Technological Development, CNPq Brazil
Corresponding Author Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Estrada do Bem Querer, 3293-3391 - Candeias, Vitória da Conquista 45029-094, Brazil. freiremeloufba@gmail.com
Key Words Helicobacter pylori; Virulence factors; CagA; Gastric cancer; EPIYA motifs; Hit-and-run carcinogenesis
Core Tip CagA is a translocated effector protein that induces morphofunctional modifications in gastric epithelial cells and persistent chronic gastric inflammation. Upon translocation, the bacterial oncoprotein acts as a promiscuous scaffold or hub protein, which is capable of disrupting multiple host signaling pathways, thereby inducing precancerous cellular alterations. This article aims at performing a general approach on Helicobacter pylori- and CagA-related oncogenic mechanisms as well as to discuss the novelties and perspectives in this field.
Publish Date 2022-11-21 04:25
Citation Freire de Melo F, Marques HS, Rocha Pinheiro SL, Lemos FFB, Silva Luz M, Nayara Teixeira K, Souza CL, Oliveira MV. Influence of Helicobacter pylori oncoprotein CagA in gastric cancer: A critical-reflective analysis. World J Clin Oncol 2022; 13(11): 866-879
URL https://www.wjgnet.com/2218-4333/full/v13/i11/866.htm
DOI https://dx.doi.org/10.5306/wjco.v13.i11.866
Full Article (PDF) WJCO-13-866.pdf
Full Article (Word) WJCO-13-866.docx
Manuscript File 79141_Auto_Edited-LM_Kerr C_Clear Copy.docx
Answering Reviewers 79141-Answering reviewers.pdf
Audio Core Tip 79141-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 79141-Conflict-of-interest statement.pdf
Copyright License Agreement 79141-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 79141-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 79141-Language certificate.pdf
Peer-review Report 79141-Peer-review(s).pdf
Scientific Misconduct Check 79141-Bing-Gao CC-2.png
Scientific Editor Work List 79141-Scientific editor work list.pdf