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11/21/2022 9:21:57 AM | Browse: 435 | Download: 1315
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Received |
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2022-08-06 01:39 |
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Peer-Review Started |
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2022-08-06 01:42 |
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First Decision by Editorial Office Director |
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2022-09-05 09:42 |
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Return for Revision |
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2022-09-05 09:42 |
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Revised |
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2022-09-20 02:59 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-10-11 03:21 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-10-11 18:33 |
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Articles in Press |
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2022-10-11 18:33 |
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Edit the Manuscript by Language Editor |
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2022-10-25 17:02 |
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Typeset the Manuscript |
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2022-11-16 06:37 |
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Publish the Manuscript Online |
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2022-11-21 04:25 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Influence of Helicobacter pylori oncoprotein CagA in gastric cancer: A critical-reflective analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fabrício Freire de Melo, Hanna Santos Marques, Samuel Luca Rocha Pinheiro, Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Kádima Nayara Teixeira, Cláudio Lima Souza and Márcio Vasconcelos Oliveira |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Council for Scientific and Technological Development, CNPq Brazil |
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| Corresponding Author |
Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Estrada do Bem Querer, 3293-3391 - Candeias, Vitória da Conquista 45029-094, Brazil. freiremeloufba@gmail.com |
| Key Words |
Helicobacter pylori; Virulence factors; CagA; Gastric cancer; EPIYA motifs; Hit-and-run carcinogenesis |
| Core Tip |
CagA is a translocated effector protein that induces morphofunctional modifications in gastric epithelial cells and persistent chronic gastric inflammation. Upon translocation, the bacterial oncoprotein acts as a promiscuous scaffold or hub protein, which is capable of disrupting multiple host signaling pathways, thereby inducing precancerous cellular alterations. This article aims at performing a general approach on Helicobacter pylori- and CagA-related oncogenic mechanisms as well as to discuss the novelties and perspectives in this field. |
| Publish Date |
2022-11-21 04:25 |
| Citation |
Freire de Melo F, Marques HS, Rocha Pinheiro SL, Lemos FFB, Silva Luz M, Nayara Teixeira K, Souza CL, Oliveira MV. Influence of Helicobacter pylori oncoprotein CagA in gastric cancer: A critical-reflective analysis. World J Clin Oncol 2022; 13(11): 866-879 |
| URL |
https://www.wjgnet.com/2218-4333/full/v13/i11/866.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v13.i11.866 |
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