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1/4/2023 7:18:18 AM | Browse: 318 | Download: 1295
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Received |
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2022-08-16 10:16 |
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Peer-Review Started |
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2022-08-16 10:18 |
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First Decision by Editorial Office Director |
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2022-10-20 20:20 |
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Return for Revision |
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2022-10-20 20:20 |
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Revised |
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2022-11-02 08:27 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-11-21 03:29 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-11-21 22:39 |
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Articles in Press |
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2022-11-21 22:39 |
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Edit the Manuscript by Language Editor |
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2022-12-02 01:16 |
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Typeset the Manuscript |
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2022-12-06 08:23 |
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Publish the Manuscript Online |
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2023-01-04 05:53 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Observational Study |
| Article Title |
Impact of Helicobacter pylori virulence markers on clinical outcomes in adult populations
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Halim Roshrosh, Hanan Rohana, Maya Azrad, Tamar Leshem, Segula Masaphy and Avi Peretz |
| Funding Agency and Grant Number |
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| Corresponding Author |
Maya Azrad, PhD, Research Scientist, Department of Microbiology, Padeh Poriya Medical Center, Lower Galillee Israel, Tiberias 111508, Israel. mazrad@poria.health.gov.il |
| Key Words |
Helicobacter pylori; Virulence factors; Vacuolating cytotoxin A; Cytotoxin-associated gene A; Urease activity |
| Core Tip |
In recent years, associations have been found between virulence markers of Helicobacter pylori and gastrointestinal disorders. In parallel, several physicians in northern Israel noted a higher treatment failure rate among Arab compared to Jewish patients. This work found a significant correlation between disease severity and patient ethnicity (P = 0.002). Further, a higher level of urease activity was associated with isolates originating from the Jewish population. Moreover, higher urease activity levels were measured among CagA-/s1m1 and CagA-/s2m2 isolates. These findings are expected to advance personalization of treatment to specific strains based on their virulence factors. |
| Publish Date |
2023-01-04 05:53 |
| Citation |
Roshrosh H, Rohana H, Azrad M, Leshem T, Masaphy S, Peretz A. Impact of Helicobacter pylori virulence markers on clinical outcomes in adult populations. World J Gastroenterol 2023; 29(1): 190-199 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i1/190.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i1.190 |
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