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3/16/2023 1:25:39 AM | Browse: 178 | Download: 784
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Received |
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2022-08-17 05:17 |
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Peer-Review Started |
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2022-08-17 05:20 |
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To Make the First Decision |
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Return for Revision |
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2022-12-12 21:14 |
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Revised |
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2023-01-05 01:58 |
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Second Decision |
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2023-02-15 03:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-02-15 21:01 |
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Articles in Press |
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2023-02-15 21:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-03-09 12:44 |
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Publish the Manuscript Online |
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2023-03-15 15:41 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
miR-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-induced β-cells by targeting EZH2
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Kai Duan, Yong-Xiang Sun, Hong-Yun Wang, Yan-Yan Xu, Shi-Zhen Fan, Jin-Ya Tian, Yong Yu, Yan-Yun Zhao and Yan-Li Jiang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical Science and Technology Key Project of Henan Province |
No.2018020733 |
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| Corresponding Author |
Xiao-Kai Duan, Doctor, MMed, Chief Physician, Department of General Practice, Zhengzhou First People’s Hospital, No. 56 Dongdajie Street, Zhengzhou 450052, Henan Province, China. medicalworkers@126.com |
| Key Words |
miR-124; Enhancer of zeste homolog 2; Diabetes; Insulin secretion; Proliferation; Apoptosis |
| Core Tip |
In clinical studies, miR-124 is highly expressed in the serum of patients with diabetes and in pancreatic islet β-cells. In this study, the role and mechanism of miR-124 in diabetes was explored. miR-124 was highly expressed in the diabetic mice, suggesting that the miR-124 was involved in the pathological process of diabetes. In high glucose-induced Min6 cells, miR-124 regulated the insulin secretion, proliferation and apoptosis of islet β-cells by targeting enhancer of zeste homolog 2 (EZH2), indicating that miR-124 was involved in the pathological process of diabetes by targeting EZH2, which might provide a new idea and target for the diagnosis and treatment of diabetes. |
| Publish Date |
2023-03-15 15:41 |
| Citation |
<p>Duan XK, Sun YX, Wang HY, Xu YY, Fan SZ, Tian JY, Yu Y, Zhao YY, Jiang YL. miR-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-induced β-cells by targeting EZH2. <i>World J Diabetes</i> 2024; In press</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i3/209.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i3.209 |
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