| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Prognostic analysis of patients with combined hepatocellular-cholangiocarcinoma after radical resection: A retrospective multicenter cohort study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ge Zhang, Bo-Wen Chen, Xiao-Bo Yang, Huai-Yuan Wang, Xu Yang, Fu-Cun Xie, Xiang-Qi Chen, Ling-Xiang Yu, Jie Shi, Yin-Ying Lu and Hai-Tao Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| CAMS Innovation Fund for Medical Sciences |
2021-I2M-1-061 |
| CAMS Innovation Fund for Medical Sciences |
2021-1-I2M-003 |
| CSCO-hengrui Cancer Research Fund |
Y-HR2019-0239 |
| CSCO-MSD Cancer Research Fund |
Y-MSDZD2021-0213 |
|
| Corresponding Author |
Hai-Tao Zhao, MD, Professor, Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuai-Fu-Yuan, Wang-Fu-Jing, Beijing 100730, China. zhaoht@pumch.cn |
| Key Words |
Combined hepatocellular-cholangiocarcinoma; Radical resection; Clinicopathological factor; Integrated nomogram; Multicenter cohort |
| Core Tip |
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a relatively rare type of primary liver cancer. Hepatectomy combined with lymph node dissection is the only possible cure. In our study, we found that the prognosis for this group of patients is poor, with a 2-year survival rate of approximately 50% after radical resection. Preoperative CA19-9 Level, tumor number, tumor size and whether or not to receive tumor size and transarterial chemoembolization (TACE) after surgery were independent factors affecting overall survival. Therefore, we recommend that patients with cHCC-CCA actively receive adjuvant TACE therapy after surgery. |
| Publish Date |
2022-11-04 05:24 |
| Citation |
Zhang G, Chen BW, Yang XB, Wang HY, Yang X, Xie FC, Chen XQ, Yu LX, Shi J, Lu YY, Zhao HT. Prognostic analysis of patients with combined hepatocellular-cholangiocarcinoma after radical resection: A retrospective multicenter cohort study. World J Gastroenterol 2022; 28(41): 5968-5981 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i41/5968.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i41.5968 |
