Publication Name	World Journal of Gastroenterology
Manuscript ID	79530
Country	China

Received	2022-08-25 10:09
Peer-Review Started	2022-08-25 10:12
First Decision by Editorial Office Director	2022-09-02 20:07
Return for Revision	2022-09-02 20:07
Revised	2022-09-21 04:58
Publication Fee Transferred
Second Decision by Editor	2022-10-31 03:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-10-31 18:37
Articles in Press	2022-10-31 18:37
Edit the Manuscript by Language Editor	2022-10-26 10:18
Typeset the Manuscript	2022-11-12 07:16
Publish the Manuscript Online	2022-11-16 11:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Salvia miltiorrhiza extract may exert an anti-obesity effect in rats with high-fat diet-induced obesity by modulating gut microbiome and lipid metabolism
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Li Ai, Xian Zhang, Wei Ge, You-Bao Zhong, Hai-Yan Wang, Zheng-Yun Zuo and Duan-Yong Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No.82060836 Jiangxi Province Graduate Student Innovation Special Fund Project YC2021-B146 Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program CXTD22008
Corresponding Author	Hai-Yan Wang, PhD, Associate Professor, Formula-Pattern Research Center, Jiangxi University of Chinese Medicine, No. 1688 Meiling Road, Nanchang 330004, Jiangxi Province, China. 378278287@qq.com
Key Words	Salvia miltiorrhiza extract; Obesity; Gut microbiota; Lipid metabolism; High fat diet
Core Tip	Obesity is a major public health issue today and an obesity-related change in gut microbiota composition and its metabolite profile has been demonstrated. As a commonly used traditional Chinese medicine, Salvia miltiorrhiza extract (Sal) has many pharmacological effects, including anticoagulant, anti-inflammation, antioxidation, anti-fibrosis, anti-tumor, and organ protection. Although it has not been documented, Sal has a regulatory effect on obesity, which may be related to the gut microbiota. In the present study, we found that Sal plays a role in weight loss, lowering serum lipid levels, regulating the gut microbiota, and improving intestinal fecal metabolites in obese rats.
Publish Date	2022-11-16 11:26
Citation	Ai ZL, Zhang X, Ge W, Zhong YB, Wang HY, Zuo ZY, Liu DY. Salvia miltiorrhiza extract may exert an anti-obesity effect in rats with high-fat diet-induced obesity by modulating gut microbiome and lipid metabolism. World J Gastroenterol 2022; 28(43): 6131-6156
URL	https://www.wjgnet.com/1007-9327/full/v28/i43/6131.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i43.6131

Full Article (PDF)	WJG-28-6131.pdf
Full Article (Word)	WJG-28-6131.docx
The ARRIVE Guidelines	79530-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	79530_Auto_Edited-LM.docx
Answering Reviewers	79530-Answering reviewers.pdf
Audio Core Tip	79530-Audio core tip.mp3
Biostatistics Review Certificate	79530-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	79530-Conflict-of-interest statement.pdf
Copyright License Agreement	79530-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	79530-Institutional animal care and use committee statement.PDF
Non-Native Speakers of English Editing Certificate	79530-Language certificate.pdf
Peer-review Report	79530-Peer-review(s).pdf
Scientific Misconduct Check	79530-Bing-Chen YL-2.png
Scientific Editor Work List	79530-Scientific editor work list.pdf
CrossCheck Report	79530-CrossCheck report.pdf