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1/18/2023 9:50:25 AM | Browse: 32 | Download: 71
Publication Name World Journal of Virology
Manuscript ID 79581
Country/Territory Turkey
2022-08-27 19:56
Peer-Review Started
2022-08-27 19:58
To Make the First Decision
Return for Revision
2022-09-27 11:53
2022-10-03 18:11
Second Decision
2022-11-21 03:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-11-22 03:05
Articles in Press
2022-11-22 03:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-11-17 08:03
Typeset the Manuscript
2023-01-12 03:26
Publish the Manuscript Online
2023-01-18 03:45
ISSN 2220-3249 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title Severe acute respiratory syndrome coronavirus 2 may cause liver injury via Na+/H+ exchanger
Manuscript Source Invited Manuscript
All Author List Medine Cumhur Cure and Erkan Cure
Funding Agency and Grant Number
Corresponding Author Medine Cumhur Cure, MD, Associate Professor, Department of Biochemistry, Private Tanfer Hospital, Mecidiyeköy, Aytekin Kotil Cd. No: 25, Şişli, Istanbul 34394, Turkey. medinecure@yahoo.com
Key Words Liver; Hepatocyte; Severe acute respiratory syndrome coronavirus 2; COVID-19; Na+/H+ exchanger; Sodium-proton pump
Core Tip Severe acute respiratory syndrome coronavirus 2 readily infects the liver by angiotensin-converting enzyme 2. Increased angiotensin II causes Na+/H+ exchanger (NHE) overstimulation allowing the accumulation of Na+ and Ca2+ in hepatocytes. Thus, hepatocytes are damaged and eventually die. Increased cytokine release increases fibrinogen levels, enhancing thrombotic events. Cytokine storms can be triggered by NHE overstimulation. Severe acute respiratory syndrome coronavirus 2-induced NHE overstimulation can change bile acid structure, which disrupts gut microbiota and can trigger cytokine storms. Liver damage from the virus can be considered the most important cause of disease progression and mortality.
Publish Date 2023-01-18 03:45
Citation Cumhur Cure M, Cure E. Severe acute respiratory syndrome coronavirus 2 may cause liver injury via Na+/H+ exchanger. World J Virol 2023; 12(1): 12-21
URL https://www.wjgnet.com/2220-3249/full/v12/i1/12.htm
DOI https://dx.doi.org/10.5501/wjv.v12.i1.12
Full Article (PDF) WJV-12-12.pdf
Full Article (Word) WJV-12-12.docx
Manuscript File 79581_Auto_Edited-LM.docx
Answering Reviewers 79581-Answering reviewers.pdf
Audio Core Tip 79581-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 79581-Conflict-of-interest statement.pdf
Copyright License Agreement 79581-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 79581-Language certificate.pdf
Peer-review Report 79581-Peer-review(s).pdf
Scientific Misconduct Check 79581-Bing-Chang KL-2.png
Scientific Editor Work List 79581-Scientific editor work list.pdf