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12/23/2022 11:10:11 AM | Browse: 162 | Download: 506
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Received |
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2022-09-05 02:17 |
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Peer-Review Started |
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2022-09-05 02:19 |
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To Make the First Decision |
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Return for Revision |
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2022-09-30 08:58 |
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Revised |
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2022-10-12 13:30 |
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Second Decision |
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2022-11-22 03:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-11-23 06:08 |
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Articles in Press |
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2022-11-23 06:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-11-30 01:08 |
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Publish the Manuscript Online |
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2022-12-23 10:01 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Immunological classification of hepatitis B virus-positive hepatocellular carcinoma by transcriptome analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sheng-Wei Li, Li-Fan Han, Yin He and Xiao-Sheng Wang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao-Sheng Wang, PhD, Associate Professor, Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, No. 639 Longmian Avenue, Jiangning District, Nanjing 211198, Jiangsu Province, China. xiaosheng.wang@cpu.edu.cn |
| Key Words |
Hepatitis B virus; Hepatocellular carcinoma; Immunological classification; Transcriptomics; Tumor immunity; Cancer immunotherapy |
| Core Tip |
First, for the first time, we identified immune-specific subtypes of hepatitis B virus (HBV) + hepatocellular carcinoma (HCC) based on immune signature scores and demonstrated that this new subtyping method was reproducible in three different datasets. Second, our subtyping method captures the comprehensive heterogeneity of HBV+ HCC in the tumor microenvironment, genomic integrity, protein expression profiles, DNA methylation profiles, tumor stemness, intratumor heterogeneity, and clinical outcomes. Third, our data suggest that it is copy number alterations but not tumor mutations responsible for the different immunity between the “hot” and “cold” tumor subtypes in HBV+ HCC. Finally, our identification of the immune-specific subtypes of HBV+ HCC may provide new insights into the tumor biology and identify the HBV+ HCC patients beneficial from immunotherapy. |
| Publish Date |
2022-12-23 10:01 |
| Citation |
Li SW, Han LF, He Y, Wang XS. Immunological classification of hepatitis B virus-positive hepatocellular carcinoma by transcriptome analysis. World J Hepatol 2022; 14(12): 1997-2011 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i12/1997.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i12.1997 |
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