ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Microbiology |
Manuscript Type |
Minireviews |
Article Title |
Development of Epstein-Barr virus-associated gastric cancer: infection, inflammation, and oncogenesis
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Manuscript Source |
Invited Manuscript |
All Author List |
Hisashi Iizasa, Andi Visi Kartika, Sintayehu Fekadu, Shunpei Okada, Daichi Onomura, Afifah Fatimah Azzahra Ahmad Wadi, Mosammat Mahmuda Khatun, Thin Myat Moe, Jun Nishikawa and Hironori Yoshiyama |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Grant-in-Aid for Scientific Research From the Ministry of Education, Culture, Science and Technology of Japan |
21K07054 (Hironori Yoshiyama) |
Grant-in-Aid for Scientific Research From the Ministry of Education, Culture, Science and Technology of Japan |
22K07101 (Hisashi Iizasa) |
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Corresponding Author |
Hironori Yoshiyama, MD, PhD, Professor, Department of Microbiology, Shimane University Faculty of Medicine, 89-1 Enyacho, Izumo 693-8501, Shimane, Japan. yosiyama@med.shimane-u.ac.jp |
Key Words |
Helicobacter pylori; Epstein-Barr virus; Epstein-Barr virus-associated gastric cancer; Coreceptor; Inflammation; Oncogenesis |
Core Tip |
Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) tumor cells originate from a single cell clone infected with EBV. In contrast, it is reported that more than 95% of patients with gastric cancer have a history of Helicobacter pylori (H. pylori) infection. Accordingly, it has long been argued that H. pylori infection may have some effect on the development of EBVaGC, a subtype of gastric cancer. It is also a mystery that the number of gastric cancer patients is higher in Asia, South America, and the Middle East. We will reorganize the role of H. pylori and EBV infections in gastric cancer formation. |
Publish Date |
2022-11-25 02:19 |
Citation |
Iizasa H, Kartika AV, Fekadu S, Okada S, Onomura D, Wadi AFAA, Khatun MM, Moe TM, Nishikawa J, Yoshiyama H. Development of Epstein-Barr virus-associated gastric cancer: infection, inflammation, and oncogenesis. World J Gastroenterol 2022; 28(44): 6249-6257 |
URL |
https://www.wjgnet.com/1007-9327/full/v28/i44/6249.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v28.i44.6249 |