Publication Name	World Journal of Gastroenterology
Manuscript ID	79960
Country	Brazil

Received	2022-09-12 22:36
Peer-Review Started	2022-09-12 22:38
To Make the First Decision
Return for Revision	2022-10-04 07:27
Revised	2022-10-07 22:14
Second Decision	2022-11-18 04:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-11-19 00:45
Articles in Press	2022-11-19 00:45
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-12-15 12:14
Typeset the Manuscript	2022-12-28 06:02
Publish the Manuscript Online	2023-01-06 02:52

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Cristiane Valle Tovo, Angelo Zambam de Mattos, Gabriela Perdomo Coral, Giovana D P Sartori, Livia Villela Nogueira, Gustavo Tovo Both, Cristiane A Villela-Nogueira and Angelo A de Mattos
Funding Agency and Grant Number
Corresponding Author	Cristiane Valle Tovo, MD, PhD, Associate Professor, Department of Internal Medicine, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite 245, Porto Alegre 90050170, RS, Brazil. cris.tovo@terra.com.br
Key Words	Non-alcoholic fatty liver disease; Nonalcoholic steatohepatitis; Hepatocellular carcinoma; Genetic variants; Microbiota; Obesity
Core Tip	Cirrhosis is an emerging major cause of the development of hepatocellular carcinoma (HCC), but in non-alcoholic fatty liver disease (NAFLD), up to 50% of patients with HCC had no clinical or histological evidence of cirrhosis. In the present study, we evaluated data regarding the epidemiology, the pathophysiology, the histopathological aspects, the current recommendations, and the novel perspectives in surveillance of non-cirrhotic NAFLD-related HCC. We believe that using non-invasive methods can guide the selection of patients who need to undergo screening and a surveillance program.
Publish Date	2023-01-06 02:52
Citation	Tovo CV, de Mattos AZ, Coral GP, Sartori GDP, Nogueira LV, Both GT, Villela-Nogueira CA, de Mattos AA. Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis. World J Gastroenterol 2023; 29(2): 343-356
URL	https://www.wjgnet.com/1007-9327/full/v29/i2/343.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i2.343

Full Article (PDF)	WJG-29-343.pdf
Full Article (Word)	WJG-29-343.docx
Manuscript File	79960_Auto_Edited-LM-Language editing-Webster J-Clear.docx
Answering Reviewers	79960-Answering reviewers.pdf
Audio Core Tip	79960-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	79960-Conflict-of-interest statement.pdf
Copyright License Agreement	79960-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	79960-Language certificate.pdf
Peer-review Report	79960-Peer-review(s).pdf
Scientific Editor Work List	79960-Scientific editor work list.pdf
CrossCheck Report	79960-CrossCheck report.pdf