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1/20/2023 1:55:59 PM | Browse: 38 | Download: 49
Publication Name World Journal of Gastroenterology
Manuscript ID 80059
Country/Territory Italy
Received
2022-09-15 11:15
Peer-Review Started
2022-09-15 11:17
To Make the First Decision
Return for Revision
2022-11-26 09:26
Revised
2022-12-03 13:23
Second Decision
2022-12-27 03:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-12-27 19:40
Articles in Press
2022-12-27 19:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
2023-01-05 21:15
Typeset the Manuscript
2023-01-12 08:40
Publish the Manuscript Online
2023-01-20 13:48
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Cytotoxic synergism of Clostridioides difficile toxin B with proinflammatory cytokines in subjects with inflammatory bowel diseases
Manuscript Source Invited Manuscript
All Author List Gabrio Bassotti, Alessandro Fruganti, Fabrizio Stracci, Pierfrancesco Marconi and Katia Fettucciari
Funding Agency and Grant Number
Corresponding Author Gabrio Bassotti, MD, PhD, Associate Professor, Department of Medicine, Gastroenterology and Hepatology Section, University of Perugia Medical School, Piazza Lucio Severi, San Sisto 06156, Italy. gabassot@tin.it
Key Words Inflammatory bowel diseases; Clostridioides difficile infection; Cytokines; Tumour necrosis factor-alpha; Interferon-gamma; necrosis; Apoptosis; Cytotoxic synergism
Core Tip Clostridioides difficile (C. difficile) is an opportunistic pathogen which diffusion is progressively increasing worldwide. Among the categories at risk, particularly susceptible are patients with inflammatory bowel diseases, due to altered immunological status and the therapies adopted that favour intestinal dysbiosis and colonization by the germ. Recent in vitro studies also suggest that the infection might be favoured by the strong cytotoxic synergism between C. difficile toxin B and pro-inflammatory cytokines tumour necrosis factor-a and interferon-g. The therapeutic approaches are however still limited, and those presently available rely on antibiotic therapy and faecal transplantation.
Publish Date 2023-01-20 13:48
Citation Bassotti G, Fruganti A, Stracci F, Marconi P, Fettucciari K. Cytotoxic synergism of Clostridioides difficile toxin B with proinflammatory cytokines in subjects with inflammatory bowel diseases. World J Gastroenterol 2023; 29(4): 582-596
URL https://www.wjgnet.com/1007-9327/full/v29/i4/582.htm
DOI https://dx.doi.org/10.3748/wjg.v29.i4.582
Full Article (PDF) WJG-29-582.pdf
Full Article (Word) WJG-29-582.docx
Manuscript File 80059-Review-Filipodiav2CL.docx
Answering Reviewers 80059-Answering reviewers.pdf
Audio Core Tip 80059-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 80059-Conflict-of-interest statement.pdf
Copyright License Agreement 80059-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 80059-Language certificate.pdf
Peer-review Report 80059-Peer-review(s).pdf
Scientific Misconduct Check 80059-Bing-Chen YL-2.png
Scientific Editor Work List 80059-Scientific editor work list.pdf