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2/15/2023 10:56:11 AM | Browse: 508 | Download: 1636
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Received |
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2022-09-22 02:30 |
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Peer-Review Started |
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2022-09-22 02:32 |
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First Decision by Editorial Office Director |
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2022-10-21 23:38 |
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Return for Revision |
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2022-10-24 05:35 |
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Revised |
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2022-11-04 04:52 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-12-30 03:28 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-12-31 05:51 |
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Articles in Press |
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2022-12-31 05:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-02-07 06:46 |
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Publish the Manuscript Online |
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2023-02-15 00:44 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
microRNA-627-5p inhibits colorectal cancer cell proliferation, migration and invasion by targeting Wnt2
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong-Yan Zhao, Teng-Fei Yin, Xi-Zhen Sun, Yuan-Chen Zhou, Qian-Qian Wang, Ge-Yu-Jia Zhou and Shu-Kun Yao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Key Development Plan for Precision Medicine Research |
No. 2017YFC0910002 |
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| Corresponding Author |
Shu-Kun Yao, Doctor, MD, PhD, Chief Physician, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
miR-627-5p; Wnt2; Colorectal cancer; β-catenin; Progression |
| Core Tip |
It has been well established that miRNAs play vital roles in modulating cancer-related pathways, thereby regulating colorectal cancer (CRC) growth and metastasis. The study comprehensively explored the function of microRNA-627-5p (miR-627-5p), a rarely reported miRNA in CRC. miR-627-5p mimics restrained CRC cells invasion, migration, proliferation, and promoted cell apoptosis, indicated its suppressive effects on CRC development. A dual luciferase reporter test showed miR-627-5p directly binds with the 3’-untranslated region of Wnt2. Furthermore, miR-627-5p prevented the aggressive behaviours of cancer cells via inhibiting the activation of the canonical Wnt signalling. Strategies targeting the miR-627-5p/Wnt2/β-catenin signalling might be a new treatment option for CRC. |
| Publish Date |
2023-02-15 00:44 |
| Citation |
Zhao DY, Yin TF, Sun XZ, Zhou YC, Wang QQ, Zhou GYJ, Yao SK. microRNA-627-5p inhibits colorectal cancer cell proliferation, migration and invasion by targeting Wnt2. World J Gastrointest Oncol 2023; 15(2): 318-331
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| URL |
https://www.wjgnet.com/1948-5204/full/v15/i2/318.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i2.318 |
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